Have a lot of experience and am studying to be a Clinical MSW. Several reports suggest an association between mothers who take these drugs in the first trimester of pregnancy and congenital abnormalities in male and female babies. Taking 50,000 IU vitamin D weekly. Patients with a past history of recurrent episodes of abnormal uterine bleeding may benefit from planned menstrual cycling with AYGESTIN. Although it is not clear that these events were drug related, you should check with your healthcare provider about the risks to your unborn child of any medication taken during pregnancy.You should avoid using Aygestin during pregnancy. However, Aygestin is contraindicated in markedly impaired liver function or liver disease.No pharmacokinetic drug interaction studies investigating any drug-drug interactions with Aygestin have been conducted.Aygestin (norethindrone acetate tablets USP) is indicated for the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer. He or she may advise you to stop using the drug.Discontinue Aygestin tablets and call your healthcare provider right away if you experience sudden partial or complete loss of vision, blurred vision, or sudden onset of bulging eyes, double vision, or migraine.Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.These are not all the possible side effects of progestin and/or estrogen therapy. It may harm them.This leaflet provides a summary of the most important information about progestin and/or estrogen therapy. I am on Paxil and one of the side effects is "sexual dysfunction" which translates as it takes me like an hour or more to cum.If you have sex every day, this will be a problem. [This message has been edited by seeseerider (edited September 21, 2000).] Volume of distribution of norethindrone is about 4 L/kg.Norethindrone undergoes extensive biotransformation, primarily via reduction, followed by sulfate and glucuronide conjugation. Patients with a past history of recurrent episodes of abnormal uterine bleeding may benefit from planned menstrual cycling with Aygestin.Initial daily dosage of 5 mg Aygestin for two weeks. Dosage should be increased by 2.5 mg per day every two weeks until 15 mg per day of Aygestin is reached. Do not give Aygestin tablets to other people, even if they have the same symptoms you have. Any of these conditions may cause death or serious long-term disability. I have been on Paxil for about 2 1/2 years now.Best of luck and if you need more info on MAO inhibitor or SSRI's post it. Figure 1. The mean terminal elimination half-life of norethindrone following a single dose administration of Aygestin is approximately 9 hours.The effect of age on the pharmacokinetics of norethindrone after Aygestin administration has not been evaluated.The effect of race on the disposition of norethindrone after Aygestin administration has not been evaluated.The effect of renal disease on the disposition of norethindrone after Aygestin administration has not been evaluated. The Paxil has forced me to be more in to the foreplay, thus pleasing my girl more.My body has never got accustomed to the Paxil, that is , it has not gotten easier as my body acclimates to the meds. The majority of metabolites in the circulation are sulfates, with glucuronides accounting for most of the urinary metabolites.Plasma clearance value for norethindrone is approximately 0.4 L/hr/kg. The pharmacokinetic parameters of norethindrone following single oral administration of Aygestin in 29 healthy female volunteers are summarized in Table 1.The effect of food administration on the pharmacokinetics of Aygestin has not been studied.Norethindrone is 36% bound to sex hormone-binding globulin (SHBG) and 61% bound to albumin. Caution should be exercised when progestins are administered to a nursing woman.The following adverse reactions have been observed in women taking progestins:Therapy with Aygestin must be adapted to the specific indications and therapeutic response of the individual patient.2.5 to 10 mg Aygestin may be given daily for 5 to 10 days to produce secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen.Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing Aygestin therapy. Progestins are prescribed for several reasons: Progesterone, a natural hormone that the body makes during pregnancy, has not caused problems. Norethindrone acetate is contraindicated during pregnancy as it may cause fetal harm when administered to pregnant women.