Isosorbide mononitrate is approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva. Dose adjustments of either class of agents may be necessary.Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction, causing falsely low readings in serum cholesterol determinations.No evidence of carcinogenicity was observed in rats exposed to isosorbide mononitrate in their diets at doses of up to 900 mg/kg/day for the first 6 months and 500 mg/kg/day for the remaining duration of a study in which males were dosed for up to 121 weeks and females were dosed for up to 137 weeks. Mechanism of Action. In particular, dialysis is known to be ineffective in removing isosorbide mononitrate from the body.No specific antagonist to the vasodilator effects of isosorbide mononitrate is known, and no intervention has been subject to controlled study as a therapy of isosorbide mononitrate overdose. Isosorbide mononitrate is intended for use in the prophylactic treatment of angina pectoris. Dizziness was rarely associated with withdrawal from these studies. See USP Controlled Room Temperature. Administration of Isosorbide Mononitrate Extended-Release Tablets once daily, taken early in the morning on arising, provided at least 12 hours of antianginal activity.In a placebo-controlled parallel study, 30, 60, 120 and 240 mg of Isosorbide Mononitrate Extended-Release Tablets were administered once daily for up to 6 weeks. 1993;17 Suppl 2:S41-5. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. 1994 Sep;35(9):1290-3. doi: 10.1136/gut.35.9.1290.Jones AL, Bangash IH, Walker J, Simpson KJ, Finlayson ND, Hayes PC.Gut. Exercise tolerance tests using the Bruce Protocol were conducted prior to and at 4 and 12 hours after the morning dose on days 1, 7, 14, 28 and 42 of the double-blind period. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. Isosorbide Mononitrate Extended-Release Tablets, during long-term use over 42 days dosed at 120 mg once daily, continued to improve exercise performance at 4 hours and at 12 hours after dosing but its effects (although better than placebo) are less than or at best equal to the effects of the first dose of After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%.
Isosorbide mononitrate belongs to the group of medicines called nitrates. mononitrate, isomannide mononitrate, isosorbide-2-mononitrate, and 5-ISMN. Do not take Imdur, Monoket, or ISMO if you are allergic to isosorbide mononitrate or any ingredients contained in this drug.Keep out of reach of children. Clinical experience for organic nitrates reported in the literature identified a potential for severe hypotension and increased sensitivity to nitrates in the elderly. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.Each tablet, for oral administration, contains either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. These animal doses are about Neonatal survival and development and incidence of stillbirths were adversely affected when pregnant rats were administered oral doses of 750 (but not 300) mg isosorbide mononitrate/kg/day during late gestation and lactation. Chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence. Patients should resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide mononitrate, since loss of headache may be associated with simultaneous loss of antianginal efficacy. Check with your Severe interactions of isosorbide mononitrate include:Serious interactions of isosorbide mononitrate include:Moderate interactions of isosorbide mononitrate include:Mild interactions of isosorbide mononitrate include: This information does not contain all possible interactions or adverse effects.
Unable to load your delegates due to an error We studied the effect and mechanism of action of oral administration of isosorbide-5-mononitrate (Is-5-Mn) (20 mg), which, unlike the dinitrate, does not require hepatic biotransformation to a vasoactive metabolite on portal and systemic haemodynamics in 11 patients with portal hypertension complicating cirrhosis.