It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. Blood pressure should be monitored at regular intervals, particularly during dosage escalation or whenever dosage has been altered, and patients should be advised not to rise abruptly from a sitting or recumbent position.Moderate Potential Hazard, Moderate plausibility. Applies to: AlcoholismThe use of neuroleptic agents is contraindicated in patients with acute alcohol intoxication exhibiting depressed vital signs. Severe respiratory depression and respiratory arrest may occur. This is because the amount of risperidone in your body is increased, or both medications may cause the same side effects. Although the pharmacokinetics of risperidone do not seem to be significantly altered in patients with liver disease, the mean free fraction of risperidone in plasma has been shown to increase by about 35% because of the diminished concentration of both albumin and alpha1-acid glycoprotein. If not treated promptly, priapism can cause irreversible damage to the erectile tissue. You should not need a new prescription for this medication to be refilled. Major Potential Hazard, High plausibility. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Your dosage, drug form, and how often you take the drug will depend on:This medication hasn’t been studied in children younger than 13 years. In patients with preexisting drug-induced TD, initiating or increasing the dosage of neuroleptic therapy may temporarily mask the symptoms of TD but could eventually worsen the condition. Anxiety and kidney disease. The risk of torsade de pointes is progressively increased as the degree of prolongation becomes greater. These drugs are often used to treat similar conditions.Risperidone works by affecting the amount of certain chemicals called neurotransmitters that occur naturally in your brain. • ‘Anxiety is a normal reaction to stressful situations, and even high levels of anxiety can be healthy and beneficial at times. While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile. This is because the amount of risperidone in your body may be decreased. Therapy with these drugs should be administered cautiously in patients with a history of seizures or other predisposing factors, such as head trauma, CNS abnormalities, and alcoholism.Moderate Potential Hazard, High plausibility. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. In controlled trials, treatment with some atypical antipsychotic drugs was also associated with an increased risk of cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, in elderly patients with dementia- related psychosis. Patients with preexisting low white blood cell count may be at increased risk. Symptoms can includeIf you have an allergic reaction, call your doctor or local poison control center right away. Additional signs may include elevated creatine phosphokinase, myoglobinuria, and acute renal failure. Applies to: Priapism, Peyronie's Disease, Sickle Cell Anemia, Thalassemia, Multiple Myeloma, LeukemiaAtypical antipsychotic agents with alpha-adrenergic blocking effects may cause priapism. If you drink alcohol, talk to your doctor about whether risperidone is safe for you.Newborn babies born to mothers taking this drug may have withdrawal symptoms. It comes as an oral tablet, an orally disintegrating tablet, and an oral solution. Risperidone is a prescription drug. Electrolyte disturbances such as hypokalemia and hypomagnesemia may augment the prolongation effect of risperidone on the QT interval and should be corrected prior to institution of risperidone therapy. The clinical significance of this observation with respect to long-term neuroleptic therapy is unknown. They may increase your dosage more slowly to reduce your risk of side effects.This medication hasn’t been studied in children younger than 10 years. Applies to: Liver DiseaseRisperidone is metabolized by the liver to the principal active metabolite, 9-hydroxyrisperidone. Require a prior authorization for this drug pediatric patients with congenital or acquired QT interval syndromes... Website services, content, and products are for informational purposes only with atypical antipsychotics be! Explain the connection between CKD and neuropsychiatric disorders prior authorization for this drug oral solution risk of having a or. 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