2. 28.Danazol suppresses the pituitary-ovarian axis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, hepatic adenoma, hepatocellular injury, hepatocellular jaundice and hepatic failure have been reported (see Abnormalities in laboratory tests may occur during therapy with Danazol including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins.The following reactions have been reported, a causal relationship to the administration of Danazol has neither been confirmed nor refuted; In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Long QT syndrome is an inherited heart rhythm problem where the heart muscle takes longer than normal to recharge between beats. The physician therefore should be alert to this possibility. Available for Android and iOS devices. Abnormalities in semen volume, viscosity, sperm count, and motility may occur in patients receiving long-term therapy.Hepatic dysfunction, as evidenced by reversible elevated serum enzymes and/or jaundice, has been reported in patients receiving a daily dosage of Danazol of 400 mg or more. If a patient becomes pregnant while taking Danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.Patients should be watched closely for signs of androgenic effects some of which may not be reversible even when drug administration is stopped.Because Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. At least ten different products were identified in feces.The reported elimination half-life of Danazol is variable across studies. These QT-prolonging medications include methadone, certain antibiotics, cyclobenzaprine, and certain cancer medicines. Long QT syndrome is uncommon, affecting about 1 in every 2,000 people. The only other demonstrable hormonal effect is weak androgenic activity. The two primary metabolites excreted in the urine are 2-hydroxymethyl Danazol and ethisterone. In rabbits, the administration of Danazol on days 6 to 18 of gestation at doses of 60 mg/kg/day and above (2 to 4 times the human dose) resulted in inhibition of fetal development.Safety and effectiveness in pediatric patients have not been established.Clinical studies of Danazol did not include sufficient numbers of subjects aged 65 and over to determine the safety and effectiveness of Danazol in elderly patients.The following events have been reported in association with the use of Danazol:Androgen like effects include weight gain, acne and seborrhea. Imprinted with black ink stylized Orange opaque cap/orange clear body capsule. Use of danazol in pregnancy is contraindicated. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. If you experience any of the following symptoms call your doctor immediately: yellowing of the skin or eyes, pain in stomach area, extreme tiredness, or unusual bleeding or bruising.