If the insulin dose is between 20 and 40 units daily, the patient may be placed directly on MICRONASE Tablets 5 mg daily as a single dose. Simvastatin is metabolised through the CYP3A4 pathway. Initial dose: 10 mg orally once a day in the evening Maintenance dose: 10 to 40 mg orally once a day in the evening Maximum dose: 40 mg orally once a day in the evening Comments:-Doses should be individualized according to the goal of therapy; dose adjustments should be made at intervals of 4 weeks or more. (See Transfer of patients from other oral antidiabetic regimens to MICRONASE should be done conservatively and the initial daily dose should be 2.5 to 5 mg. Applies to the following strengths: 80 mg; 5 mg; 10 mg; 20 mg; 40 mg; 20 mg/5 mL; 40 mg/5 mLMild to moderate renal dysfunction: No adjustment recommendedActive liver disease or unexplained transaminase elevations: ContraindicatedAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. When transferring patients from chlorpropamide, particular care should be exercised during the first two weeks because the prolonged retention of chlorpropamide in the body and subsequent overlapping drug effects may provoke hypoglycemia.Some Type II diabetic patients being treated with insulin may respond satisfactorily to MICRONASE. In June 2011, FDA restricted the use of the highest approved dose of simvastatin (80 mg) to reduce the risk of muscle injury (myopathy). Micronase Tablets contain glyburide, which is an oral blood-glucose-lowering drug of the sulfonylurea class. A maintenance dose of 5 mg of MICRONASE Tablets provides approximately the same degree of … We comply with the HONcode standard for trustworthy health information - Some patients, particularly those receiving more than 10 mg daily, may have a more satisfactory response with twice-a-day dosage.MICRONASE is not recommended for use in pregnancy or for use in pediatric patients.In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function, the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. Concomitant use of CYP3A4 inhibitors has the potential to increase exposure to simvastatin1. Available for Android and iOS devices. Progressive withdrawal of insulin and increase of MICRONASE in increments of 1.25 to 2.5 mg every 2 to 10 days is then carried out. Both amlodipine and diltiazem are substrates and inhibitors of CYP3A4 2 3and therefore increase the plasma concentration (AUC0-24h) and maximum plasma concentration (Cmax) of simvastatin when they are co-administered. … The appearance of persistent acetonuria with glycosuria indicates that the patient is a Type I diabetic who requires insulin therapy.MICRONASE Tablets should be added gradually to the dosing regimen of patients who have not responded to the maximum dose of metformin monotherapy after four weeks (see With concomitant glyburide and metformin therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. In addition to the usual monitoring of urinary glucose, the patient's blood glucose must also be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, Short-term administration of MICRONASE may be sufficient during periods of transient loss of control in patients usually controlled well on diet.The usual starting dose of MICRONASE Tablets is 2.5 to 5 mg daily, administered with breakfast or the first main meal. Select one or more newsletters to continue. Simvastatin (Zocor) is used to treat high cholesterol and to reduce risk of heart disease. Those patients who may be more sensitive to hypoglycemic drugs should be started at 1.25 mg daily. Select one or more newsletters to continue. If the insulin dose is more than 40 units daily, a transition period is required for conversion to MICRONASE. A maintenance dose of 5 mg of MICRONASE Tablets provides approximately the same degree of blood glucose control as 250 to 375 mg chlorpropamide, 250 to 375 mg tolazamide, 500 to 750 mg acetohexamide, or 1000 to 1500 mg tolbutamide.When transferring patients receiving more than 40 units of insulin daily, they may be started on a daily dose of MICRONASE Tablets 5 mg concomitantly with a 50% reduction in insulin dose. Lovastatin doses should not exceed 40 mg orally per day in patients receiving concomitant amiodarone or verapamil therapy.