Some classes of antibiotics are more likely to result in this interaction, notably fluoroquinolones, macrolides, cyclines, cotrimoxazole and some cephalosporins.Vecuronium (non depolarising curaremimetic): Metronidazole can potentialise the effects of vecuronium.5 Fluoro-uracile: increase in the toxicity of 5 fluoro-uracile due to a decrease of its clearance.Lithium: lithium retention accompanied by evidence of possible renal damage has been reported in patients treated simultaneously with lithium and Metronidazole. 500 mg q12h) in patients with CrCl < 10 mL/min
This period may only be exceeded in individual cases after a very strict benefit-risk assessment. interaction of the reduced intermediate products with intracellular targets, and
Hypersensitivity to metronidazole, or other nitroimidazole derivatives Alcohol: disulfiram-like effect (violent retching,
In newborns with a gestation age < 40 weeks, accumulation of metronidazole can occur during the first week of life, therefore the concentrations of metronidazole in serum should preferably be monitored after a few days of therapy.Oral medication could be given, at the same dose regimen. Some tertiary references
4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Although Metronidazole has been shown to be carcinogenic in certain species of mice, it was not carcinogenic in either rats or guinea pigs. The bags are overwrapped with a protective plastic pouch composed of polyamide/polypropylene, which serves only to provide physical protection to the bags.Outer carton contents: 20 bags of 100ml, 50 bags of 100ml and 60 bags of 100ml.Use only if the solution is clear, without visible particles and if the container is undamaged. 7-10 days Trichomoniasis: 15 mg/kg/day PO divided q8h x 7 daysRenal failure: Inconclusive. Therefore it is recommended that patients should not drive or use machines.There are no data available on adverse reactions from Baxter-sponsored clinical trials conducted with Metronidazole. re-dosing of 7.5 mg/kg should occur q6hProphylaxis in sexual assault victims: 2g PO x 1 dose + IM
Most indices of testicular toxicity were restored within 2 months after cessation of treatment, whereas the lower testicular and epididymal weights had improved but were still observed. Some adverse reactions to metronidazole such as seizure, dizziness, optic neuropathy, may impair the ability to drive or operate machines (see section 4.8). There is no specific treatment for Metronidazole overdose, Metronidazole infusion should be discontinued. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. Daily peroral metronidazole at approximately 6-times the maximum human daily dose for ≥2 weeks caused testicular toxicity in male mice. The following adverse reactions have been reported with Metronidazole, listed by MedDRA System Organ Class (SOC), Preferred Term and frequency. CBC, urinalysis, BUN, SCr, AST and ALT, diarrhea, No evidence of risk
To be taken into consideration by patients on a controlled sodium diet.Patients should be advised to discontinue consumption of alcoholic beverages or alcohol-containing products before, during, and up to 72hours after taking metronidazole because of a disulfram-like effect (abdominal cramps, nausea, headaches, flushing, vomiting and tachycardia). CNS symptoms and CNS lesions, are generally reversible within days to weeks upon discontinuation of metronidazole.Aseptic meningitis can occur with metronidazole. Various schedules are possible. However dosage reduction may be necessary when excessive concentrations of metabolites are found.In patients undergoing haemodialysis, Metronidazole should be re-administered immediately after haemodialysisIn patients with advanced hepatic insufficiency a dosage reduction with serum level monitoring is necessary. Caution is needed in patients with hepatic encephalopathy. This effect is probably caused by interaction with DNS and different metabolites.Pharmacotherapeutic group: Antibacterials for systemic use: imidazole derivativesPharmacotherapeutic group: Antiprotozoals: nitroimidazole derivativesMetronidazole has antibacterial and antiprotozoal actions and is effective against anaerobic bacteria and against Trichomonas vaginalis and other protozoa including Entamoeba histolytica and Giardia lamblia.The MIC breakpoints separating susceptible from intermediately susceptible and intermediately susceptible from resistant organisms are as following:The prevalence of acquired resistance may vary geographically and with time for selected species and local information is desirable, particularly when treating severe infections.