As the theory suggests, the smaller particles allowed the use of higher flow rates without loss of efficiency.For method optimization, a systematic examination of flow rate was conducted. Figure The order of elution does not vary between the two methods: Impurity A is first, followed by E, C, B, D, with F and G co-eluting, and finally the Miconazole.The method was validated with respect to parameters laid out by the International Conference on Harmonization (ICH 2002), including linearity, precision, accuracy, specificity, LOD, and LOQ.Each of the impurities and the API gave a linear response over the concentration range tested. Development and validation of a simple stability-indicating high performance liquid chromatographic method for the determination of miconazole nitrate in bulk and cream formulationsSimultaneous determination of metronidazole and miconazole in pharmaceutical dosage formsAnalysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC)High-pressure liquid chromatographic (HPLC) analysis of imidazole antifungals in commercial dosage formsDetermination of miconazole in human saliva using high-performance liquid chromatographyAnalysis of come antifungal drugs by spectrophotometric and spectrofluorometric methods in different pharmaceutical dosage formsDevelopment and validation of UPLC method for determination of primaquine phosphate and its impuritiesEvaluation of ultra performance liquid chromatography Part I.
The column used was a Thermo Scientific Hypersil Gold C18 Column (50 mm x 4.6 mm i.d., 1.9 µm particle size) (Waltham, MA).An isocratic separation was carried out using a mobile phase consisting of acetonitrile–methanol–ammonium acetate (1.5 w/v) (30:32:38 v/v) and was used at a flow rate of 2.5 mL/min with UV detection at 235 nm. Infezioni ungueali, applicare 1-2 volte al giorno; Altri tipi di infezioni, 2 volte al giorno (il trattamento generalmente dura anche dopo la guarigione per circa 10 giorni) A profile of sample and impurity breakdown was presented. Search for other works by this author on:
It is also both economically and environmentally friendly due to the decrease in solvent consumption. It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). The flow rate was increased in increments taking pressure and resolution into account. Sci., 19, 1981, 219-226. (NCI04) For Permissions, please email: journals.permissions@oup.com
The mobile phase was filtered through 0.45 µm nylon filters and degassed in an ultrasonic bath prior to use.A standard solution (50 ppm) of Miconazole and impurities was prepared using acetonitrile–methanol–ammonium acetate (1.5 w/v) (30:32:38 v/v) as the diluent. Dispersive Liquid–Liquid Microextraction Combined with Microwave Demulsification for Determination of FAME Residuals in Biodiesel Wastewater
It was completely validated with acceptable data for all parameters tested.The authors would like to thank Limerick Institute of Technology Internal Research Support Fund for their help in funding the project, Janssen Ireland Ltd. for the generous donation of chemicals and technical support, and Shannon ABC for the use of equipment.Oxford University Press is a department of the University of Oxford. Toxicol., 11, 1987, 154-163.ass: Standard non-polar; Column diameter: 0.32 mm; Column length: 12 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 290 C; Start time: 1 min; CAS no: 22916478; Active phase: SE-30; Carrier gas: He; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Neill, G.P. Click to predict properties on the Chemicalize site
N. O'Connor, M. Geary, M. Wharton, P. Sweetman, The Determination of Miconazole and its Related Production Impurities Together with Basic Solution Stability Studies Using a Sub 2 µm Chromatographic Column, A selective and sensitive method for the analysis of Miconazole and its associated impurities is developed.