It is taken by mouth. This medicine helps to increase the levels of insulin produced after a meal and decreases the amount of Merck notes: Sitagliptin, sold under the brand name Januvia among others, is a medication used to treat diabetes mellitus type 2. Sitagliptin phosphate (MK-0431) is a potent, orally active inhibitor of DPP-IV with an IC50 of 19 nM in Caco-2 cell extracts. Find all the information about Sitagliptin phosphate monohydrate for cell signaling research. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. SITAGLIPTIN contains the active substance sitagliptin which is a member of a class of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) that lowers blood sugar levels in adult patients with type 2 diabetes mellitus. All Rights Reserved.Tags: buy Sitagliptin | Sitagliptin supplier | purchase Sitagliptin | Sitagliptin cost | Sitagliptin manufacturer | order Sitagliptin | Sitagliptin distributor
Molecular Formula: C20H19F6N5O5, Molecular Weight: 523.39 InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1 Molecular Weight(MW): 407.31 Sitagliptin is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. (1 u is equal to 1/12 the mass of one atom of carbon-12) *The name THE MERCK INDEX is owned by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, N.J., U.S.A., and is licensed to The Royal Society of Chemistry for use in the U.S.A. and Canada. (1 u is equal to 1/12 the mass of one atom of carbon-12)Answers to questions you may have can be found in the inhibitor handling instructions. With respect to the pharmacology of the metabolites of sitagliptin, M1, M2, and M5 were shown to be ~300-, 1000-, and 1000-fold less active, respectively, than sitagliptin as DPP-4 inhibitors (IC50 values of ~5, >20, and >20 µM, respectively, versus 18 nM for sitagliptin). The Selleck dilution calculator is based on the following equation:Enter the chemical formula of a compound to calculate its molar mass and elemental composition:To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u).
Name Sitagliptin phosphate Drug Entry Sitagliptin. Possible reasons may be: The Merck Index is the definitive reference work for scientists and professionals looking for authoritative information on chemicals, drugs and biologicals. Parent Compound: CID 4369359 (Sitagliptin) Component Compounds: CID 313 (Hydrochloric acid) CID 4369359 (Sitagliptin) Dates:
In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. Sitagliptin Phosphate Monohydrate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. It is also available within a single pill as metformin/sitagliptin.. Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. SITAGLIPTIN contains the active substance sitagliptin which is a member of a class of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) that lowers blood sugar levels in adult patients with type 2 diabetes mellitus. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Sitagliptin treatment potentiated the GLP-1 response to glucose by 1.5-fold (P < 0.05). Sitagliptin(MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus Label,4,1,2.The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar Label,1. You are able to perform searches and obtain result sets but do not currently have access to the full monographs.