Patients should be instructed to take Azulfidine in evenly divided doses preferably after meals. Approximately 15% of a dose of SSZ is absorbed as parent and is metabolized to some extent in the liver to the same two species. Less common or rare adverse reactions include:The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. The presence of clinical signs such as sore throat, fever, pallor, purpura, or jaundice may be indications of serious blood disorders or hepatotoxicity. In more advanced cases, central nervous system symptoms such as drowsiness, convulsions, etc., may be observed. If anuria is present, restrict fluids and salt, and treat appropriately. In fast acetylators, the mean plasma half-life of SP is 10.4 hours while in slow acetylators, it is 14.8 hours. This page provides all possible translations of the word muad'dib in … Information and translations of Muad'Dib in the most comprehensive dictionary definitions resource on the web. Goiter production, diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides. Acetylsulfapyridine (AcSP), the principal metabolite of SP, is approximately 90% bound to plasma proteins.As mentioned above, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. This creature is admired by Fremen for its ability to survive in the open desert. SP can also be metabolized to 5-hydroxy-sulfapyridine (SPOH) and N-acetyl-5-hydroxy-sulfapyridine. If such signs or symptoms are present, the patient should be evaluated immediately. Azulfidine Dosage and Administration. Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Alkalinize urine. What does Muad'Dib mean? Approximately 60% of the Caucasian population can be classified as belonging to the slow acetylator phenotype. alternative version of the common word 'mad'. In cases where the outcome was reported, bloody stools or diarrhea resolved in the infant after discontinuation of sulfasalazine in the mother or discontinuation of breastfeeding. Patients are at highest risk for these events early in therapy, with most events occurring within the first month of treatment. Muad'Dib. Power supply. Cross-sensitivity may exist with these agents. In Terminology of the Imperium, the glossary of the 1965 novel Dune, Herbert provides the following definition:. The clinical implication of this is unclear; however, in a small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed a higher incidence of adverse events.Gender appears not to have an effect on either the rate or the pattern of metabolites of SSZ, SP, or 5-ASA.Only after critical appraisal should Azulfidine Tablets be given to patients with hepatic or renal damage or blood dyscrasias. These subjects will display a prolonged plasma half-life for SP (14.8 hours vs 10.4 hours) and an accumulation of higher plasma levels of SP than fast acetylators. Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. Symptoms of overdosage may include nausea, vomiting, gastric distress, and abdominal pains. SP apparently is well absorbed from the colon with an estimated bioavailability of 60%. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. These events have been chosen for inclusion due to a combination of seriousness, frequency of reporting, or potential causal connection to mesalamine:There is evidence that the incidence and severity of toxicity following overdosage are directly related to the total serum sulfapyridine concentration. Paul’s messianic name is Muad'Dib (“ mu'adibs ” means “teacher” in Arabic), they call the sandworms Shai-Hulud (Shai meaning “Thing" and "Hulud" meaning "Immortality”), and Paul’s death commando bodyguard, the Fedaykin, derives its name from the Arabic Fedayeen, a term used to describe military groups willing to sacrifice themselves. Caution should be exercised when Azulfidine is administered to a nursing mother.There are reports with limited data of bloody stools or diarrhea in human milk fed infants of mothers taking sulfasalazine. Select one or more newsletters to continue. Due to limited data, a causal relationship between sulfasalazine exposure and bloody stools or diarrhea cannot be confirmed or denied. Should any of these occur, the patient should seek medical advice. A single oral dose of 12 g/kg was not lethal to mice.Gastric lavage or emesis plus catharsis as indicated. occur after the first few doses of Azulfidine, they are probably due to increased serum levels of total sulfapyridine and may be alleviated by halving the daily dose of Azulfidine and subsequently increasing it gradually over several days. Caution should be exercised when considering the use of sulfasalazine in patients with a history of recurring or chronic infections or with underlying conditions or concomitant drugs which may predispose patients to infections.Severe hypersensitivity reactions may include internal organ involvement, such as hepatitis, nephritis, myocarditis, mononucleosis-like syndrome (i.e., pseudomononucleosis), hematological abnormalities (including hematophagic histiocytosis), and/or pneumonitis including eosinophilic infiltration.Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported in association with the use of sulfasalazine.