These stress fracture injuries may contribute to lost duty days and reduce deployment readiness because of physical limitation.Service members in the U.S. Armed Forces participate in intense physical activity when training and performing their job responsibilities. 2018;21(11):1139–1146.2. Cyclooxygenase-2 inhibitors in human skeletal fracture healing. Bone Rep. 2015;1:1–8.17. J Sports Med. 2000;82(5):655–658.25. Stress fractures, active component, U.S. Armed Forces, 2004–2010.
Nonsteroidal anti-inflammatory drug prescriptions are associated with increased stress fracture diagnosis in the US Army population. Lisowska B, Kosson D, Domaracka K. Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing; the effects of these drugs on bone repair. Do nonsteroidal anti-inflammatory drugs affect bone healing? Find helpful links and resources based on who you are...
While both NSAIDs were able to relieve the pain associated with stress fracture, exposure to naproxen had negative effects on bone healing and increased the risk for future stress fracture by reducing bone toughness. Biol Res Nurs. Blackwell KA, Raisz LG, Pilbeam CC. Letter to the Editor: G6PD Deficiency in the Tafenoquine Era
Nadolski, CE. J Bone Joint Surg Am. DHA Director visits Naval Hospital Pensacola
A total of 28,141 controls were selected, resulting in a total sample size of 35,177 Of the 7,036 incident stress fracture cases identified in the first part of the study, 5,295 were diagnosed on or after 1 October 2015, after the transition to the ICD-10 coding system, and were included in the second part of the analysis This study found that active component service members who had previously received any NSAIDs experienced a 70% increased incidence in stress fracture diagnoses compared to those who had not received any NSAIDs. Widespread use of prescriptions nonsteroidal antiinflammatory drugs among U.S. Army active duty soldiers. Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. ScientificWorldJournal. Adolphson P, Abbaszadegan H, Jonsson U, Dalén N, Sjöberg HE, Kalén S. No effects of piroxicam on osteopenia and recovery after Colles’ fracture. A critical analysis. Prior receipt of NSAIDs was associated with an increased incidence of stress fractures (adjusted incidence rate ratio=1.70; 95% confidence interval [CI]:1.58-1.82; p<.0001). Evans CE, Butcher C. The influence on human osteoblasts in vitro of non-steroidal anti-inflammatory drugs which act on different cyclooxygenase enzymes. Random selection was performed if more than 4 controls were matched to a case. Kaji H, Sugimoto T, Kanatani M, Fukase M, Kumegawa M, Chihara K. Prostaglandin E2 stimulates osteoclast-like cell formation and boneresorbing activity via osteoblasts: role of cAMPdependent protein kinase. Prevalence of and factors associated with vitamin D deficiency in 4,793 Japanese patients with rheumatoid arthritis. 2011;18(5):8–11.4. 2004;70(8):1452–1454.9. Wood AM, Hales R, Keenan A, et al. Researchers concluded there was indeed an association between NSAID and acetaminophen use and stress fractures in soldiers, and it was particularly high during periods of increased physical activity. Among stress fracture cases, prior receipt of NSAIDs was associated with increased diagnosis of delayed healing (adjusted odds ratio=1.41; 95% CI: 1.12-1.77; p=.004). 2018;12;1809–1814.14. Vitamin D and chronic pain: promising correlates. Jankowski CM, Shea K, Barry DW, et al. However, several studies suggest that NSAIDs increase risk of stress fractures, especially during times of intense physical training. The model adjusted for sex, race/ethnicity, service, age, time in service, recruit status, occupation, and diagnosis of vitamin D deficiency.
Sonneville KR. Clipboard, Search History, and several other advanced features are temporarily unavailable. A total of 7,036 cases of stress fracture and 28,141 matched controls were identified between June 2014 and December 2018 and included in the analysis. The same adjusted incidence rate ratio was calculated for just the Army population. The physical activity can potentially result in overuse injuries because the repetitive force exerted by the musculoskeletal system may cause cumulative microtraumatic damage leading to strains, sprains, and stress fractures.Hughes and colleagues examined the association between stress fractures and nonsteroidal antiinflammatory drugs (NSAIDs) in a U.S. Army population and found that both NSAIDs and acetaminophen potentially increase the risk for stress fractures.The use of NSAIDs to treat swelling and pain from fractures has been widely debated.