Gerhard Domagk was the man credited with the discovery of Prontosil or which he received the 1939 Nobel Prize in Physiology or Medicine.After the success of Prontosil, many sulfonamides were developed which dramatically improved the treatment of infectious diseases. Furosemide injection is used for intravenous administration by bolus administration or continuous infusion. Although it increases circulation to the kidneys, it does not help kidney function, and is not recommended for kidney disease. A dark-red azo dye was introduced in 1935 as the first commercially available antibiotic and marketed under the brand name Prontosil. Drug Intelligence Publications, Inc, Hamilton, IL, 1988.Product Information: Lasix(R), furosemide. The need for new and better compounds remained high. In the kidneys, salt (composed of sodium and chloride), water, and other small molecules normally are filtered out of the blood and into the tubules of the kidney. It may also cause interactions with anesthetics, so its use should be related to the veterinarian if the animal is going into surgery, and it decreases the kidneys' ability to excrete The drug is best not used during pregnancy or in a lactating mare, as it has been shown to be passed through the placenta and milk in studies with other species. Some related compounds were found to be diuretics, which led to the discovery of furosemide in 1959. It should not be used in horses with Furosemide is detectable in urine 36–72 hours following injection. Furosemide was the result of traditional medicinal chemistry. This prompted researchers to develop improved diuretics.Modification of the sulfonamide structure led eventually to The chemical dynasty originating with sulfanilamide is shown in the figure below.Furosemide was patented in 1959 and first approved in 1964 in tablet form for the treatment of edema. The diuretic effects are put to use most commonly in horses to prevent bleeding during a race. These patients were more likely to arrive by ambulance and had more signs of congestion compared with the nonearly treatment group 1. It started with the first commercial antibiotic. Sometime in the early 1970s, furosemide's ability to prevent, or at least greatly reduce, the incidence of bleeding (Furosemide is also used in horses for pulmonary edema, congestive heart failure (in combination with other drugs), and allergic reactions. When tested these as antimicrobial agents these were much more effective and less toxic than anything tested before. Furosemide tablets for oral administration contain Furosemide as the active ingredient and the following inactive ingredients: corn starch, lactose anhydrous, magnesium stearate, pregelatinized starch, microcrystalline cellulose, sodium starch glycolate, and colloidal silicon dioxide. Bacteria, but not eukaryotic cells, have to synthesize their own folic acid to support DNA synthesis. Pergamon Press, New York, NY, 1990.AHFS Drug Information 2004. Sulfonamides prevent folic acid synthesis in bacteria, and hence inhibition prevents bacterial multiplication.The discovery of sulfonamides and the elucidation of their mechanism propelled medicinal chemistry forward. Under its brand name LasixFurosemide is one of the 20 most commonly prescribed medications. Elwell RJ1, Spencer AP, Eisele GAMA Department of Drugs: Drug Evaluations Subscription, American Medical Association, Chicago, IL, 1990.Knoben JE & Anderson PO (Eds): Handbook of Clinical Drug Data, 6th. It may also be used for the treatment of high blood pressure. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Furosemide (Lasix), the first of the loop diuretics, debuted in 1965. Chemically, it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. What does the nurse know about furosemide (Lasix) in regards to its choice of treatment? Parenteral furosemide was recommended for temporary use If gastrointestinal absorption is impaired or oral medication is not practical for any reason.Furosemide was the first of the four loop diuretics to be introduced. "Lasix" redirects here. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Initially by intramuscular injection, or by slow intravenous injection, or by intravenous infusion. Results Among 1,291 AHF patients treated with intravenous furosemide within 24 h of ED arrival, the median D2F time was 90 min (IQR: 36 to 186 min), and 481 patients (37.3%) were categorized as the early treatment group.