Based on human experience from epidemiological studies, ondansetron is suspected to cause orofacial malformations when administered during the first trimester of pregnancy.In one cohort study including 1.8 million pregnancies, first trimester ondansetron use was associated with an increased risk of oral clefts (3 additional cases per 10 000 women treated; adjusted relative risk, 1.24, (95% CI 1.03-1.48)).The available epidemiological studies on cardiac malformations show conflicting results.Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Volume was related to age and was lower in adults than in infants and children. BREAST MILK IS BEST FOR MOST BABIES.ALWAYS READ THE LABEL. Find the best price for Ondansetron with a free prescription discount card and save ondansetron 8mg tablets price up to 80% off both name brand and generic Ondansetron. THIS MEDICINE MAY NOT BE RIGHT FOR YOU. On the days of chemotherapy, patients received either ondansetron 5 mg/mA double-blind randomised placebo-controlled trial (S3AB4003) in 438 patients aged 1 to 17 years demonstrated complete control of emesis on worst day of chemotherapy in: The disposition of ondansetron following oral, intramuscular (IM) and intravenous (IV) dosing is similar with a terminal half life of about 3 hours and steady state volume of distribution of about 140 L. Equivalent systemic exposure is achieved after IM and IV administration of ondansetron.A 4mg intravenous infusion of ondansetron given over five minutes results in peak plasma concentrations of about 65ng/ml. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. • 73% of patients when ondansetron was administered intravenously at a dose of 5 mg/m This site uses cookies. Ondansetron was significantly more effective than placebo in preventing nausea and vomiting. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. The role of ondansetron in opiate-induced emesis is not yet established.The effect of ondansetron on the QTc interval was evaluated in a double blind, randomized, placebo and positive (moxifloxacin) controlled, crossover study in 58 healthy adult men and women.Ondansetron doses included 8 mg and 32 mg infused intravenously over 15 minutes. The adverse event profiles in children and adolescents were comparable to that seen in adults. The half-life in the patient population aged 1 to 4 month was reported to average 6.7 hours compared to 2.9 hours for patients in the 5 to 24 month and 3 to 12 year age range. Early Phase I studies in healthy elderly volunteers showed a slight age-related decrease in clearance, and an increase in half-life of ondansetron. Ondansetron prolongs the QT interval in a dose-dependent fashion. The majority of the blindness cases reported resolved within 20 minutes. Alternative brands works in the same way as the existing medicine. Your doctor has weighed the expected benefits of you taking Ondansetron-RL Tablets against the risks this medicine could have for you. Ondansetron (Generic) Tablets. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Women of childbearing potential should consider the use of contraception. READ THE WARNINGS BEFORE PURCHASE.ALWAYS READ THE LABEL. All children received three 0.15 mg/kg doses of intravenous ondansetron, administered 30 minutes before the start of chemotherapy and then at four and eight hours after the first dose. Click here for a complete list! (See section 4.4). The singleOral dosing can commence twelve hours later and may be continued for up to 5 days (Table 2).The total dose over 24 hours (given as divided doses) must not exceed adult dose of 32 mg.b The total dose over 24 hours (given as divided doses) must not exceed adult dose of 32 mg.The elimination half-life of ondansetron is not altered in subjects classified as poor metabolisers of sparteine and debrisoquine. price for products displayed on this website is: the supplier's recommended retail price for the product, provided that this is a price at or above which at Please select the desired brand. As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration.In patients with adenotonsillar surgery prevention of nausea and vomiting with ondansetron may mask occult bleeding. The half life of the elimination phase following suppository administration is determined by the rate of ondansetron absorption, not systemic clearance and is approximately six hours.