A4g��$k����~�`�;d^��0X�����m��|��q����(��.���mIv����)}��NHt�����Z�Mw� �u����"������D,�;+�I��H���r?n�v������9�f25YR�2���!�m&!Ye�9ԓ�TU�{%�I@W'�G^ ���$I��7��[������5�8�[�L��?$͌�PX�z�c;]��N�H�D�i*.�?R��Nb]�LE~��rJ�*vKC��&-B�(�)�[���Z�Ɇ�����3m��e�p��w_�s�!_e_�3��x5��/� �5w2
Nimodipine was found not to be carcinogenic in a 91-week mouse study but the high dose of 1800 ppm nimodipine-in-feed (546 to 774 mg/kg/day) shortened the life expectancy of the animals. 1994 Mar;28(3):352-8. Twenty-nine of 479 (6.1%) placebo treated patients also reported adverse experiences. endstream
endobj
52 0 obj<>stream
0000009408 00000 n
The 30 mg capsules are packaged in unit dose foil pouches and supplied in cartons containing 100 capsules. Certain macrolide antibiotics are known to inhibit the cytochrome P450 3A4 system and the potential for drug interaction cannot be ruled out at this stage. In each, a judgment was made as to whether any late-developing deficit was due to spasm or other causes, and the deficits were graded. Available for Android and iOS devices. It was patented in … In general, the capsules should be swallowed whole with a little liquid, preferably not less than one hour before or two hours after meals. The Nimotop brand name has been discontinued in the U.S. Course. These medications are not usually taken together. Such patients should have their blood pressure and pulse rate monitored closely and should be given a lower dose (see Intestinal pseudo-obstruction and ileus have been reported rarely in patients treated with nimodipine. WebMD provides common contraindications for Nimotop Oral. Nevertheless, blood pressure should be carefully monitored during treatment with Nimotop based on its known pharmacology and the known effects of calcium channel blockers. The use of nimodipine in combination with rifampin is therefore contraindicated (see Previous chronic administration of the antiepileptic drugs phenobarbital, phenytoin or carbamazepine markedly reduces the bioavailability of orally administered nimodipine. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. The soft gelatin capsule shell contains gelatin, glycerin, purified water and titanium dioxide.Nimodipine is a calcium channel blocker. Author information: (1)Department of Pharmacy Practice, School of Pharmacy, Southwestern Oklahoma State University, Baptist Medical Center, Oklahoma City 73112. Generic Name: Nimodipine Class: Dihydropyridines - Calcium-Channel Blocking Agents, Dihydropyridine - Calcium Antagonists VA Class: CV200 Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester Molecular Formula: C 21 H 26 N 2 O 7 CAS Number: 66085-59-4 Medically reviewed by Drugs… Using these medicines together may cause abnormally low blood pressure.If you experience dizziness, lightheadedness, or weakness, especially upon standing, contact your doctor. Therefore, macrolide antibiotics should not be used in combination with nimodipine (see Azithromycin, although structurally related to the class of macrolide antibiotic is void of CYP3A4 inhibition.No formal studies have been performed to investigate the potential interaction between nimodipine and anti-HIV protease inhibitors. Dosage should be reduced to one 30 mg capsule every 4 hours with close monitoring of blood pressure and heart rate; if necessary, discontinuation of the treatment should be considered.Upon co-administration with CYP 3A4 inhibitors or CYP 3A4 inducers a dose adjustment may be necessary.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Grapefuit juice is to be avoided (See PRECAUTIONS, Drug Interactions). The structural formula is:Nimodipine is a yellow crystalline substance, practically insoluble in water.Nim…