We would like to show you a description here but the site won’t allow us. Stimulation of Vagus By Phenylephrine Increases the Efficiency Antidepressant effect of amitriptyline, phenylephrine and their combinations in the Porsolt test.The duration of immobilization in the Porsolt test, secAmitriptyline, 0.3, i.m. For the purpose of quantitative assessment of the locomotor activity for each dose of the test substance, the mean horizontal and mean vertical activity was calculated. At the same time, adrenomimetic phenylephrine, which as stimulant of vagal afferents after systemic administration is not inferior in activity to adrenaline, is allowed for oral administration, since does not break down in the digestive tract.
Behavioral depression in rats was studied in the standard two-day swimming test of Porsolt [7, 8]. Combined single i.m. This method is suitable for the safe treatment of moderate severe forms of epilepsy, depression, medium-intensity pain, not resistant to drugs, in the treatment of which good results are achieved when using CNS agents alone in high therapeutic doses, which cause undesirable but tolerable side effects for most patients. If you take an MAOI, you should not take cold, flu, or cough medicine that contains a decongestant (such as phenylephrine and pseudoephedrine) or dextromethorphan. Side sedative effect of substances was evaluated in the "open field" test (OP).
It is known that a single or subacute introduction of a high dose of amitriptyline causes side sedative effect in rats, since it significantly reduces motor activity in the open field test [9, 12, 13]. In our experiments, it was shown that stimulation of vagal afferents of the gastric mucosa by adrenomimetics (adrenaline, phenylephrine) when administered systemically at threshold doses potentiates the therapeutic effect of small doses of analgesics, antidepressants, neuroleptics, antiepileptics, and other CNS drugs to the level of therapeutic effects of therapeutic doses of the CNS drugs, but does not enhance their side effects [1, 4]. Phenylephrine with a single intramuscular (i.m.) Do not stop using any medications without first talking to your doctor.Applies to: C Phen (chlorpheniramine / phenylephrine)Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. It follows that stimulation of the vagal afferents of the gastric mucosa by threshold doses of phenylephrine first leads to potentiation of the antidepressant effect of amitriptyline in a submaximal dose of 3 mg/kg without the development of a sedative effect and, secondly, potentiates the antidepressant effect and eliminates the sedative effect of amitriptyline in high dose of 30 mg/kg. Combined use of phenylephrine in a threshold dose with amitriptyline and other antidepressants in a submaximal dose (1/3-1/10 of the maximum therapeutic dose) allows to obtain a fast and safe antidepressant effect, impossible with antidepressants in themselves in a high dose that causes side sedative, stressogenic and anxiogenic action. For diazepam, phenylephrine, a combination of diazepam with phenylephrine, and control, the mean severity of seizures in points was determined, as well as the number of rats with generalized seizures (4-6 points) and local clonic seizures (2-3 points) as % of the total number of rats in a group. Please enable it to take advantage of the complete set of features! or i.v.) Talk to your doctor or pharmacist if you have any questions or concerns.Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some mixtures of medications can lead to serious and even fatal consequences.Gavreto (pralsetinib) is an oral selective RET kinase inhibitor for the...Onureg (azacitidine) is a nucleoside metabolic inhibitor indicated for the...Qdolo (tramadol hydrochloride) is an opioid agonist indicated in adults for ...Xaracoll (bupivacaine hydrochloride) is a fully bioresorbable collagen implant...The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.