For some individuals, omeprazole discontinuation symptoms might linger for up to 2 weeks after onset – whereas for others, omeprazole discontinuation symptoms might remain for up to 3 months after onset. Taper off of omeprazole: Unless you’re transitioning from omeprazole to another proton-pump inhibitor (PPI) or acid-reducing medication, it is not recommended to quit omeprazole “cold turkey” (especially if you’re a long-term and/or high-dose user). Desf. That said, it is known that omeprazole’s effects can linger in the system for 3 to 5 days following the final dose.Once omeprazole is fully eliminated from the body and the effects of its final dose have passed, the body may enter withdrawal (this might occur around 5 days after the final dose). We used the keywords: proton pump inhibitor, proton pump inhibitors, side effects, adverse effects and complications. The truth is, restoring normal stomach function after extended PPI treatment is a rocky affair marked by successes and setbacks. Translocation of bacteria from the gut to ascites is thought to play a key role, and two meta‐analyses based on numerous patients have demonstrated a two‐ to threefold increase in odds of SBP among patients treated with PPIs It has recently been demonstrated that PPI‐induced hypochlorhydria can cause intestinal bacterial overgrowth of It has been hypothesized that micro‐aspiration of gastric contents containing more bacteria due to PPI‐induced hypochlorhydria may lead to lung colonization and subsequent pneumonia. If the symptoms disappear, the likely cause is rebound acid secretion.The clinical effect of rebound increase in acid secretion with withdrawal of PPIs is therefore relatively small and limited to a small group of people who are on PPIs for no good reason. Some physicians attribute the severe symptoms that people experience when they stop PPIs to rebound acid secretion, but this is probably a minor factor (if it is a factor at all).It has been estimated that approximately 30% of patients taking long-term PPIs for GERD may not have GERD at allRefluxMD suggests that patients in this group try a test of PPI withdrawal. This means that the effects (and side effects) of a drug can be studied in the population that actually is the target of the drug and not in a selected group of test subjects. Thus, the available evidence does not convincingly demonstrate that PPI users are at increased risk of developing dementia.During the past decades, the use of PPIs has been increasing and concerns of various possible side effects have been raised. Wade Thompson reports honoraria for speaking about PPI deprescribing at academic conferences.Please check your email for instructions on resetting your password. with a history of severe erosive oesophagitis, withdrawal of PPIs should only be considered after discussion with an appropriate specialist. Suspected side effects are related to increased susceptibility to infections due to PPI‐induced hypochlorhydria and altered intestinal microbiome, side effects related to secondary hypergastrinaemia, impeded absorption of micronutrients or idiosyncratic reactions causing kidney disease or dementia.For most of the suggested side effects, the concern has been raised based on associations between the suspected side effect and long‐term use of PPIs demonstrated in observational studies. Anyone who cannot tolerate this medication might decide to stop treatment and face potential omeprazole withdrawal symptoms.Many experts question whether discontinuation symptoms can occur after stopping omeprazole treatment.