Version: 7.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Lab Test Considerations: Assess CBC and renal and hepatic function before and periodically during therapy. 4) doses. Apply to either upper chest or back (below the neck, above the waist), upper thigh, or to the outer surface of the upper arm. Decreases GI motility, possibly affecting absorption of other drugs.Dry mouth, constipation, somnolence, headache, diarrhea, nausea, tachycardia, blurred vision, dry eyes, other anticholinergic effects.Copyright © 2020 Haymarket Media, Inc. All Rights Reserved We comply with the HONcode standard for trustworthy health information - Patients should be informed that alcohol may enhance the drowsiness caused by anticholinergic agents such an oxybutynin (see section 4.7) There are no adequate data on the use of oxybutynin in pregnant women. - Frequent urination at night caused by heart or kidney disease By continuing to browse the site you are agreeing to our policy on the use of cookies. Hyperthyroidism. The potential risk for humans is unknown. Your reactions could be impaired.Avoid becoming overheated or dehydrated during exercise and in hot weather. Megacolon. Diarrhea. Autonomic neuropathy. For alternatives for different types of pain, see our charts, Pharmacotherapy of Neuropathic Pain, Analgesics for Osteoarthritis, In the subcutaneous fertility study in rats, no effects have been reported in males, while in females, fertility was impaired (no observed adverse effect level stated to be 5 mg/kg.Do not store above 30°C. Oxybutynin, as an anticholinergic agent, may antagonize the effect of prokinetic therapies (e.g.Concomitant use with cholinesterase inhibitors may result in reduced cholinesterase inhibitor efficacy. • Anticholinergics should be used with caution in elderly patients due to the risk of cognitive Impairment. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. hallucinations, agitation, confusion, somnolence) have been reported; monitoring recommended especially in first few months after initiating therapy or increasing the dose; consider discontinuing therapy or reducing the dose if anticholinergic CNS effects develop. Therefore, a dose of 2.5mg twice a day, particularly if the patient is frail, is likely to be adequate. • Gastrointestinal disorders: Anticholinergic medicinal products may decrease gastrointestinal motility and should be used with caution in patients with gastrointestinal obstructive disorders, intestinal atony and ulcerative colitis. • Oxybutynin hydrochloride should be used with caution in the frail elderly and children who may be more sensitive to the effects of the product and in patients with autonomic neuropathy (such as those with Parkinson's disease), hepatic or renal impairment and severe gastro-intestinal motility disorders (also see … Dermal Adhesion Dermal adhesion of EMSAM was examined after application of 6 mg/24 hours selegiline patches for 10 days to the upper torso. Approximately 88% - 89% of 6 mg/24 hours selegiline patches applied to We comply with the HONcode standard for trustworthy health information - Pregnancy (Cat.B). Adults: The dosage should be determined individually, with an initial dose of 2.5 mg three times daily. Bioavailability is higher in elderly patients; AUC is 2-4-fold higher after repeated administration and half-life 3-5 times longer (se section 4.2).Pre-clinical data reveal no special hazard for humans based on studies for acute toxicology, repeat dose toxicity, genotoxicity, carcinogenic potential and local toxicity. Oxybutynin should not be used during pregnancy unless clearly necessary.When oxybutynin is used during lactation, a small amount is excreted in mother's milk. Slight, clinically insignificantpin leukocyte and neutrophilcountsmayoccur. Promethazine is a first-generation antihistamine used to treat allergies, nausea, and motion sickness.In a hospital setting, promethazine is often used to treat anaphylaxis and provide mild sedation before or after surgery. Be careful if you drive or do anything that requires you to be alert and able to see clearly.There are many other medicines that can interact with oxybutynin. Thereafter, the lowest effective dose should be selected. For non-prescription products, read the label or package ingredients carefully. This site uses cookies. Concomitant administration with a CYP 3A4 inhibitor can inhibit oxybutynin metabolism and increase oxybutynin exposure (e.g. Exposure to extreme heat. Do not take two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Avoid driving or hazardous activity until you know how oxybutynin will affect you. Thereafter, the lowest effective dose should be selected.