Been using it for 4 years high doses and reduced. I take the collagen in the morning. I've read all the post with great interest and have some questions. Another thing I use is a product called Benesom (made by Metagenics). Elderly people with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) taking antipsychotic drugs are at an increased risk for death. Generic P, which is what is in creams, even in very low doses, made my insomnia worse and Prometrium, even 25mg, made me extremely drowsy during the day. When I looked at the ingredients, I saw that it contains glycine and proline (plus Vit B complex and magnesium). Upon further research, I read with interest that glycine, an amino acid, is great for anxiety and sleep problems. For me, the worst of the bunch was Ambien (Zopiclone) and even worse, Alprazolam (Xanax). Saphris may used alone. Doctors are so quick to hand them out for just about any ailment. I will definitely try the Magnesium Glycinate though. Although this web site is not intended to be prescriptive, it is intended, and hoped, that it will induce in you a sufficient level of scepticism about some health care practices to impel you to seek out medical advice that is not captive to purely commercial interests, or blinded by academic and institutional hubris. Comment: Saphris works well for me. In adults it may be used in conjuction with lithium or valproate. I also try to avoid foods with phytoestrogens, such as flax seeds, soy etc. In fact I know they made things worse. SAPHRIS may cause serious side effects, including: I tried so many anti-depressants and sleeping tablets/tranquilizers, but they did not help. It hypes me up. I tried the estradiol patch plus various amounts and types of progesterone. It is so difficult to find properly researched information on the internet. Symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, Your doctor will need to check your progress while you are using Saphris.Store at room temperature away from moisture and heat.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Sleep, or even getting drowsy, was impossible. I am so sensitive to anything that may hype me up. How effective has estrogen been for you for sleep issues? Available for Android and iOS devices. I was in a dark place before discovering natural progesterone cream and this website.See what's being discussed, ask for help, give your thoughts or experiences, or just browse...Hi. Do not take two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Avoid becoming overheated or dehydrated during exercise and in hot weather. Unfortunately I don't know anything about thyroid problems, so can't help with that. I use quite a lot of the cream, 150mg morning and night. It is awful. Good luck, Karin Has anyone tried Saphris for sleep? Using dry hands, gently remove the tablet and place it under your tongue.Do not swallow the sublingual tablet. Finally stopped E after E dominance started causing hair loss and now just take 20-25 mg Prometrium … My hormone saliva test recentlyI had a complete hysterectomy at 38, in March when I turned 60, I went off Bio-identical hormones. We comply with the HONcode standard for trustworthy health information - Overall, once you get the package open, it is an incredible med. I am on a Magnesium supplement which contains various forms of Magnesium, but the Glycinate version sounds better. I’ve been on bio identical hormones for about a year and a half due to severe hot flashes. Select one or more newsletters to continue. I take 15mg a night and I get about 4 to 5 hours sleep a night. Drink plenty of fluids, especially in hot weather and during exercise. 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