Applies to: Renal DysfunctionThe use of nitrofurantoin is contraindicated in patients with anuria, oliguria, or significant renal impairment (CrCl < 60 mL/min). Applies to: Colitis/Enteritis (Noninfectious)Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. The drug should be withdrawn immediately if hepatitis or liver damage occurs and is felt to be drug-related. The study is created by eHealthMe based on reports of 97 people who take Paracetamol and Nitrofurantoin from the FDA, and is updated regularly. Revision date: April 15, 2020.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Periodic monitoring of renal function is recommended during prolonged therapy.Moderate Potential Hazard, Moderate plausibility. In case these names of high-risk antibiotics don’t sound familiar to you, here are common brand names: Clindamycin: Evoclin, ClindaMax, Clindagel, Clinda-Derm, and Cleocin Nitrofurantoin systemic 100 mg (Macrobid 52427-285) Long-term use has been associated with an increased risk of serious side effects.Medicines that interact with nitrofurantoin may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with nitrofurantoin. Applies to: Pulmonary ImpairmentChronic pulmonary reactions, generally in patients who have received continuous treatment for 6 months or longer have been reported with the use of nitrofurantoin. The study is created by eHealthMe based on reports the from the FDA, and is updated regularly. The antibiotics amoxicillin, nitrofurantoin or cephalosporins were not associated with increased risks. Therapy with nitrofurantoin should be administered cautiously in patients with liver disease. Select one or more newsletters to continue. Antibiotics Might Lower Effectiveness of Birth Control Pill The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus. Nitrofurantoin is an antibacterial agent with a large crystal structure (called a … Major Potential Hazard, Moderate plausibility. Available for Android and iOS devices. Antibiotics Might Lower Effectiveness of Birth Control Pill Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Start now, it's free Common medications that may interact with nitrofurantoin include:Note that this list is not all-inclusive and includes only common medications that may interact with nitrofurantoin. Since nitrofurantoin is eliminated by the kidney, risk of toxicity may also be increased.Moderate Potential Hazard, Moderate plausibility. Therapy with nitrofurantoin should be administered cautiously in patients with one or more risk factors and/or preexisting peripheral neuropathy. Since nitrofurantoin is partially metabolized by the liver, a reduced dosage may also be necessary to prevent toxicity.Major Potential Hazard, High plausibility. There is some evidence that pseudomembranous colitis, if it occurs, may run a more severe course in these patients and that it may be associated with flares in their underlying disease activity. There is no drug interaction reported. On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age. Applies to: G-6-PD DeficiencyHemolytic anemia has been reported in patients treated with nitrofurantoin, primarily in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. The offending antibiotic(s) should be discontinued if significant diarrhea occurs during therapy. The most common side effect of nitrofurantoin is an upset stomach. Most acute reactions are self-limiting and resolve spontaneously, although fatalities have been reported. If the rash becomes unbearable you will need to see your doctor. On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age. The use of nitrofurantoin has occasionally been associated with the development of peripheral neuropathy, which may be severe and irreversible. 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