These two compounds are nonselective α-blockers (i.e., antagonists of both αCompetitive inhibition of α-adrenoceptors by appropriate antagonists predominantly causes vasodilatation and a reduction of blood pressure, particularly in hypertensive patients. Tamsulosin is available in a 0.4-mg formulation. *Values are presented as mean (standard deviation). Moreover, current findings should also warn physicians to carefully suggest and combine a 5‐alphareductase inhibitor along with silodosin at least in younger patients, given that the reported high rate of ejaculatory disorders has been recently reported to result in a 3‐fold increase compared with either monotherapies (Gacci Current analysis is not devoid of limitations. In clinical medicine, they are widely used in the treatment of hypertension, angina pectoris, supraventricular tachyarrhythmias, congestive heart failure, and as secondary prevention following myocardial infarction. The recommended dose of tamsulosin (Flomax) is 0.4 mg 30 minutes after a meal every day, up to a maximum of 0.8 mg per day. Rapaflo (Silodosin) and Flomax (tamsulosin) are both alpha blockers, meaning they work at the same receptors in our bodies. Rarely, alpha-blockers can cause syncope. We sought to assess the effects of a 3‐month course of silodosin 8 mg daily dosing on sexual functioning, mainly including ejaculation and orgasm, in a cohort of 100 consecutive sexually active men in the real‐life setting. Although not all of these side effects may occur, if they do occur they may need medical attention. James J. Gugger, Megan J. Ehret, in Life-Threatening Effects of Antipsychotic Drugs, 2016. Pentamethonium, hexamethonium, and trimethaphan are examples of ganglioplegic agents. Time to symptom improvement greater than placebo may take 6 or more months. anticholinergic medications) can increase the absorption of Cardura XL® and increase its effect. Ganglionic blockade in the sympathetic ganglia accounts for their effective lowering of blood pressure, particularly in hypertensive patients. Prazosin is an effective treatment for nightmares in patients with posttraumatic stress disorder and doxazosin, terazosin, alfuzosin, tamsulosin, and silodosin are commonly used for the symptomatic treatment of benign prostatic hyperplasia (BPH). Abdullah Gul, Soner Coban, Ali Riza Turkoglu, Muhammed Guzelsoy, Murat Ozturk, Nazim Abdulkadir Kankilic, Comparative Efficacy and Safety Profile of Silodosin 4 vs 8 mg Once Daily Usage in Patients with BPH related LUTS Divided into Subgroups According to IPSS Severity, Prostate International, 10.1016/j.prnil.2020.04.002, (2020). Chapple From the everyday clinical practice standpoint, these findings sound of major importance because (i) daily dosing silodosin is highly effective in relieving LUTS/BPH (any type); (ii) treatment‐related EjDs are significantly more frequent than those described in premarketing studies; (iii) EjDs might be very bothersome because of a potential association with a concomitant orgasmic impairment in younger, sexually active men and (iv) none of the side effects (any type) persisted after drug withdrawal. All patients included were prescribed to receive daily dosing silodosin 8 mg for a 3‐month course in an outpatient setting. Patients completed the International Index of Erectile Function‐Orgasmic Function (IIEF‐OF) domain and the International Prostate Symptom Score (IPSS) both at baseline and at survey. *AUA guideline on management of benign prostatic hyperplasia (2003). Alfuzosin is available in a 10-mg formulation only and Postural hypotension, dizziness, fatigue, headache, nasal stuffiness, and retrograde ejaculation may occur. Rates and predictors of OF impairment and drug discontinuation were investigated. First, although this is the first naturalistic study specifically assessing OF in a homogenous cohort of heterosexual sexually active men, the small sample size may have limited the statistical power of the analyses. 4.3.3.3 Use of α 1-Adrenoceptor Antagonists. Of clinical interest, one out of three patients with impaired ejaculation did also complain of decreased orgasmic feeling; conversely, almost all patients reporting an impaired orgasmic feeling did also report either anejaculation or hypospermia or both. Results: In the carvedilol compared with the doxazosin group, ejection fraction diminished significantly (38% vs 42%, p < 0.05) and quality of life worsened significantly (Minnesota Living Heart Failure score 54 vs 47, p < 0.05) during the first 3 weeks of treatment. Silodosin (Rapaflo®) CYP3A strong inhibitors - Strong inhibitors of CYP3A4 can increase silodosin blood levels significantly.