Extended-release tablets need to be taken only once a day. We comply with the HONcode standard for trustworthy health information - If angina markedly worsens or acute coronary insufficiency develops, Toprol-XL administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. It is supplied by AstraZeneca Pharmaceuticals. Toprol XL (metoprolol succinate) is available in a cheaper, generic form. 0000001656 00000 n
The recommended starting dose of Toprol-XL is 25 mg once daily for two weeks in patients with NYHA Class II heart failure and 12.5 mg once daily in patients with more severe heart failure. 0000002417 00000 n
At steady state the average bioavailability of metoprolol following administration of Toprol-XL, across the dosage range of 50 to 400 mg once daily, was 77% relative to the corresponding single or divided doses of conventional metoprolol. 0000004263 00000 n
Swallow the half-tablet whole, without chewing or crushing.You will need frequent medical tests, and your blood pressure will need to be checked often.If you need surgery, tell the surgeon ahead of time that you are using metoprolol.You should not stop using Toprol-XL suddenly. If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Toprol-XL PATIENTS WITH BRONCHOSPASTIC DISEASES SHOULD, IN GENERAL, NOT RECEIVE BETA-BLOCKERS. )Advise patients to take Toprol-XL regularly and continuously, as directed, preferably with or immediately following meals. I'm on Toprol XL and have been OK on 100 mg a day for several years, but that's changed recently. All Rights Reserved. Toprol-XL is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. Beta Blocker Heart Meds Might Pose Special Risks for Women Toprol XL (metoprolol succinate) lowers the risk of death during and after a heart attack. The benefit of treating hypertension may outweigh any risks to the baby.Take Toprol-XL exactly as prescribed by your doctor. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Clinical laboratory findings may include elevated levels of serum transaminase, alkaline phosphatase, and lactate dehydrogenase.Catecholamine depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) may have an additive effect when given with beta-blocking agents. Beta Blocker Heart Meds Might Pose Special Risks for Women Can be taken with or without food. 0000026725 00000 n
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Toprol-XL may also be used for indications not in this medication guide. For additional information regarding Toprol-XL or hypertension, angina pectoris or heart failure, please visit the 300 N. Washington St., Suite 200, Falls Church, VA 22046, USACopyright © 2020. However, in the US subgroup (n=1071) and women (n=898), overall mortality and cardiovascular mortality appeared less affected. At the end of the study, the mean daily dose of Toprol-XL was 159 mg.The trial was terminated early for a statistically significant reduction in all-cause mortality (34%, nominal p= 0.00009). The protocol excluded patients with contraindications to beta-blocker use, those expected to undergo heart surgery, and those within 28 days of myocardial infarction or unstable angina. If transient worsening of heart failure occurs, consider treating with increased doses of diuretics, lowering the dose of Toprol-XL or temporarily discontinuing it. 0000035051 00000 n
Many drugs can interact with Toprol-XL, especially:any other heart or blood pressure medications, especially digitalis, clonidine, diltiazem, verapamil, quinidine, propafenone, and others;an antidepressant, especially monoamine oxidase (MAO) inhibitors (including isocarboxazid, rasagiline, selegiline, phenelzine, transcypromine, and methylene blue injection) and selective serotonin reuptake inhibitors (SSRIs) including fluoxetine, paroxetine and others; orThis list is not complete and many other drugs may interact with metoprolol succinate. Metoprolol is a racemic mixture of R- and S- enantiomers, and is primarily metabolized by CYP2D6. Can I have a small amount of alcohol on the following medications:Brilinta, prilosec, Lisinopril, Toprol-xl? In this population, Toprol-XL decreased the rate of mortality plus hospitalization, largely through a reduction in cardiovascular mortality and hospitalizations for heart failure.Toprol-XL is an extended-release tablet intended for once daily administration.