That means you need to take it with other drugs.Glimepiride is used to reduce high blood sugar levels in people with type 2 diabetes. Do not take other medicines unless they have been discussed with your doctor. Talk to your doctor about possible alternatives.This drug is chemically similar to a class of medications called sulfonamides (sulfa drugs). If you have a sulfa allergy, tell your doctor before taking this drug. Different people may feel different symptoms of low blood sugar. It is very important to follow carefully any instructions from your health care team about:Check with your doctor right away if you start having chest pain or discomfort; nausea; pain or discomfort in the arms, jaw, back, or neck; shortness of breath; sweating; or vomiting while you are using this medicine. Our website services, content, and products are for informational purposes only. It comes as an oral tablet. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. This medicine may cause dizziness, drowsiness, or less alert than they are normally. Learn about drug interactions between glimepiride oral and propranolol oral and use the RxList drug interaction checker to check drug combinations. Examples of these drugs include:These drugs can decrease the effect of glimepiride and cause high blood sugar. Have a glucagon kit available, along with a syringe or needle, and know how to use it. Healthline Media does not provide medical advice, diagnosis, or treatment. If disposing the container in the trash, label it “do not recycle.”Before you start and while you’re taking glimepiride, your doctor may check your:Glimepiride is used to treat diabetes along with diet changes and exercise. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Glimepiride reduces blood sugar levels in 2 to 3 hours. Some may be more suitable for you than others. They can either increase or decrease. Don’t throw out individual lancets into trashcans or recycling bins, and never flush them down the toilet. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). All rights reserved. These conditions may be life-threatening and require immediate medical attention. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Glimepiride is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.glimepiride is not for treating type 1 diabetes.. Glimepiride may also be used for purposes not listed in this medication guide. If you’re allergic to sulfa medications, you may be allergic to glimepiride. Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Generic drugs usually cost less. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Examples of drugs that can cause interactions with glimepiride are listed below.These drugs can increase the effect of glimepiride and cause low blood sugar. This medicine may cause serious types of allergic reactions, including anaphylaxis. Tell your doctor about the allergy and what signs you had. You’ll need to learn how to do the following:To check your blood sugar levels, you’ll need to have:Lancets are used to test your blood sugar while you’re taking glimepiride. Propranolol is a prescription drug. Stop using this medicine and check with your doctor right away if you have a blistering, peeling, or red skin rash; itching; a large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; trouble with breathing; or chest tightness while you are using this medicine.