July 2, 2009 -- Proton pump inhibitors are … Proton pump inhibitors, such as Nexium and Protonix, are a common treatment for gastric reflux and heartburn. H2 blockers, by contrast, work for 12 hours. The most common include constipation, diarrhea, flatulence, headache, These include problems with the absorption of minerals, changes in bone density, and an increased risk for certain chronic illnesses. Updated January, 2009. To avoid side effects, you will want to slowly stop Inderal LA (propranolol sustained-release capsules) as ordered by your doctor. âThey should not be given to patients with upper GI symptoms on the off chance that the symptoms are acid related.âIn response to the study, a spokesman for AstraZeneca Pharmaceuticals, which markets Prilosec and Nexium, questioned the study design and its relevance to patients with acid reflux symptoms.âThis study was conducted in healthy volunteers, and the authors acknowledge that they canât be sure that the conclusion can be carried over to patients who have started PPI therapy because of dyspeptic symptoms,â Blair Hains tells WebMD.Hains cited a 2007 review of research examining rebound acid hypersecretion, which concluded that there was not strong evidence that withdrawal from PPIs is associated with a clinically relevant increase in acid production.Calls to Takeda Pharmaceuticals, which manufacturers Prevacid, were not returned by publication time.Christina Reimer, MD, investigator, department of medical gastroenterology, Copenhagen University, Denmark. Kenneth E. L McColl, MD, dvision of cardiovascular and medical sciences, University of Glasgow, Scotland. Mel Wilcox, MD, gastroenterologist, University of Alabama School of Medicine, Birmingham. Blair Hains, spokesman, AstraZeneca Pharmaceuticals. WebMD does not provide medical advice, diagnosis or treatment. The research findings highlight the fact that PPIs should only be used for short-term relief or treatment rather than as a means to prevent gastric illnesses on a long-term basis. Ali khan M, Howden CW. Among them: Many of these adverse effects appear connected to the fact that Get nutrition tips and advice to make healthy eating easier.Harvard Health Publishing, Harvard Medical School. Sharon Gillson is a writer living with and covering GERD and other digestive issues. Call your doctor for medical advice about side effects. By using Verywell Health, you accept our Side effects not requiring immediate medical attention. Some people should stay on a PPI, even for long periods of time. In addition, if you stop suddenly after taking it for a long time, you may get extra side effects as a reaction to stopping it. Because of this, PPIs work for up to 24 hours and provide relief for up to 72 hours. Proton pump inhibitors are commonly used to treat disorders like The role of proton pump inhibitors in the management of upper gastrointestinal disorders. PPIs differ from H2 blockers in that PPIs shut down the acid pumps while H2 blockers only block the signal that trigger acid production. They all have similar mechanisms of action and similar rates of effectiveness. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. By Salynn Boyles. You may report side effects to FDA at 1-800-FDA-1088. But long-term use of the drugs has been linked to kidney problems, bone fractures and other health problems. “As a gastroenterologist, we are seeing more and more patients in clinic who have questions about whether they can stop their PPI use because they have heard about potential side effects,” says Jacob Kurlander, M.D., a clinical lecturer and gastroenterologist at Michigan Medicine. Unfortunately, abruptly stopping proton pump inhibitors can cause other problems, such as rebound acid indigestion. PPIs work by binding to a cell on the wall of the stomach called the parietal cell whose purpose it is to produce hydrochloric acid (HCL). It is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches. Prescribed inderal (propranolol) for anxiety related pvc's/adrenaline rushes/panic.Scared the inderal (propranolol) will harm my heart after researching side effects online.Help. Currently approved PPIs include:It's important to speak with your doctor to ensure that the use of a PPI is appropriate. Call your doctor right away if you have new or worse chest pain or if other heart problems occur. They have been used to treat a wide of gastric acid-related illnesses for more than 30 years and are known to be safe and effective—so much so that they've largely supplanted H2 blockers as the drug of choice These include an irregular heart rate, sweating and shaking.