These coupons are free and can be used to save up to 80% on all medications. Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of Bactrim are particularly at risk.Trimethoprim has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction.As with all drugs containing sulfonamides, caution is advisable in patients with porphyria or thyroid dysfunction.Co-administration of Bactrim and leucovorin should be avoided with High dosage of trimethoprim, as used in patients with Severe and symptomatic hyponatremia can occur in patients receiving Bactrim, particularly for the treatment of During treatment, adequate fluid intake and urinary output should be ensured to prevent crystalluria. If sulfamethoxazole/trimethoprim is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be advised of the potential hazards to the fetus.Fatalities associated with the administration of sulfonamides, although rare, have occurred due to severe reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias.Sulfonamides, including sulfonamide-containing products such as sulfamethoxazole/trimethoprim, should be discontinued at the first appearance of skin rash or any sign of adverse reaction. Occasional reports suggest that patients receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly may develop megaloblastic anemia if BACTRIM is prescribed.The efficacy of tricyclic antidepressants can decrease when coadministered with BACTRIM.BACTRIM potentiates the effect of oral hypoglycemics that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renallyIn the literature, a single case of toxic delirium has been reported after concomitant intake of sulfamethoxazole/trimethoprim and amantadine (an OCT2 substrate). This reaction is frequently dose-related (see Cases of hypoglycemia in non-diabetic patients treated with Bactrim are seen rarely, usually occurring after a few days of therapy. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Imprint on tablets (debossed): (front) BactrimAll trademarks are property of their respective owners.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy.BACTRIM is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency.BACTRIM is contraindicated in pediatric patients less than 2 months of age. Thrombocytopenia usually resolves within a week upon discontinuation of sulfamethoxazole/trimethoprim.The sulfonamides should not be used for treatment of group A β-hemolytic streptococcal infections. The patient should be monitored with blood counts and appropriate blood chemistries, including electrolytes. Bactrim (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for oral administration. The mean serum half-lives of sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications. Patients who are “slow acetylators" may be more prone to idiosyncratic reactions to sulfonamides.Patients should be instructed to maintain an adequate fluid intake in order to prevent crystalluria and stone formation.Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Imprint on tablets (debossed): (front) Bactrim DSBactrim™ TABLETS (white, round, scored) containing 80 mg trimethoprim and 400 mg sulfamethoxazole – bottles of 100 (NDC 49708-145-01). When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. OFFERING INFORMATION ON HIV/AIDS Acute Exacerbations of Chronic Bronchitis in Adults: Adjunctive treatment with Leucovorin for Pneumocystis jirovecii pneumoniaUse in the Treatment of and Prophylaxis for Pneumocystis jirovecii Pneumonia in Patients with Acquired Immunodeficiency Syndrome (AIDS): Carcinogenesis, Mutagenesis, Impairment of Fertility: FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA AND OTHER BLOOD DYSCRASIAS (SEEBACTRIM is contraindicated in pediatric patients less than 2 months of age.Urinary Tract Infections and Shigellosis in Adults and Pediatric Patients, and Acute Otitis Media in Children:Acute Exacerbations of Chronic Bronchitis in Adults: