Terazosin decreases blood pressure gradually within 15 minutes following oral administration.Patients in clinical trials of terazosin were administered once daily (the great majority) and twice daily regimens with total doses usually in the range of 5 to 20 mg/day, and had mild (about 77%, diastolic pressure 95 to 105 mmHg) or moderate (23%, diastolic pressure 105 to 115 mmHg) hypertension. Carcinoma of the prostate and BPH cause many of the same symptoms. The adverse events that were bothersome, as judged by their being reported as reasons for discontinuation of therapy by at least 0.5% of the terazosin group and being reported more often than in the placebo group, are shown in Table 2.The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. The most important lifestyle changes to lower blood pressure are to lose weight, reduce salt, fat, and alcohol in the diet, quit smoking, and exercise regularly. You must take it every day at the dose prescribed. It relaxes blood vessels, allowing blood to flow through them more easily. The disposition of the compound in animals is qualitatively similar to that in man.Terazosin capsules, USP are indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH). Updated This leaflet describes terazosin capsules as a treatment for hypertension or BPH.Blood pressure is the tension of the blood within the blood vessels. Increased fetal resorptions, decreased fetal weight and an increased number of supernumerary ribs were observed in offspring of rabbits dosed with 60 times the maximum recommended human dose. 2005 Aug;31(2):54-61.Rahardjo D, Soebadi DM, Sugandi S, Birowo P, Djati W, Wahyudi I.Int J Urol. 2010 Oct 6;(10):CD006015. The following is a guide to its administration:1 mg at bedtime is the starting dose for all patients, and this dose should not be exceeded. FOR MORE INFORMATION ABOUT TERAZOSIN CAPSULES AND HYPERTENSION OR BPH, TALK WITH YOUR DOCTOR, NURSE, PHARMACIST OR OTHER HEALTH CARE PROVIDER. The latter should also be considered if possibly blood pressure-related side effects, such as dizziness, palpitations, or orthostatic complaints, are seen within a few hours after dosing.The greater blood pressure effect associated with peak plasma concentrations (first few hours after dosing) appears somewhat more position-dependent (greater in the erect position) than the effect of terazosin at 24 hours and in the erect position there is also a 6 to 10 beat per minute increase in heart rate in the first few hours after dosing. 24689-882-01, When used to treat HYPERTENSION or BENIGN PROSTATIC HYPERPLASIA (BPH)Other important facts about terazosin capsules for BPHWhat you should know while taking terazosin capsules for hypertension or BPHTerazosin Capsules, USP Can Cause a Sudden Drop in Blood Pressure After the VERY FIRST DOSE. Therefore, treatment with 10 mg for a minimum of 4 to 6 weeks may be required to assess whether a beneficial response has been achieved. These findings (in both species) were most likely secondary to maternal toxicity. Terazosin has been shown to undergo minimal hepatic first-pass metabolism and nearly all of the circulating dose is in the form of parent drug. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials.Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. Because there are relatively few alpha-1 adrenoceptors in the bladder body, terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.Terazosin has been studied in 1222 men with symptomatic BPH. Inactive ingredients: Crospovidone, lactose (monohydrate), magnesium stearate, and microcrystalline cellulose. Discontinuation During Placebo-Controlled Trials Benign Prostatic Hyperplasia TABLE 3. Terazosin capsules were devoid of mutagenic potential when evaluated In measurements 24 hours after dosing, heart rate was unchanged.Limited measurements of peak response (2 to 3 hours after dosing) during chronic terazosin administration indicate that it is greater than about twice the trough (24 hour) response, suggesting some attenuation of response at 24 hours, presumably due to a fall in blood terazosin concentrations at the end of the dose interval. Remember that hypertension requires three, four or more different medicines (once, twice, three or four times a day) to achieve good control over several months. The patient’s ophthalmologist should be prepared for possible modifications to their surgical technique, such as the utilization of iris hooks, iris dilator rings, or viscoelastic substances. 2003 Apr;169(4):1520-5. doi: 10.1097/01.ju.0000033280.29453.72.Tacklind J, Fink HA, Macdonald R, Rutks I, Wilt TJ.Cochrane Database Syst Rev. All adverse events reported during these trials were recorded as adverse reactions. The usual recommended dose range is 1 mg to 5 mg administered once a day; however, some patients may benefit from doses as high as 20 mg per day. Asthenia, postural hypotension, dizziness, somnolence, nasal congestion/rhinitis, and impotence were the only events that were significantly (p ≤ 0.05) more common in patients receiving terazosin than in patients receiving placebo.