Ann Intern Med 78 (1973): 251-339. Ann Pharmacother 30 (1996): 41651. A combination of these two effects reduces the blood pressure.Side-effects are uncommon, as the dose needed to lower blood pressure is low. Magil AB "Drug-induced acute interstitial nephritis with granulomas." Unauthorized Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Side effects of thiazide diuretics are dose related and include: dizziness and lightheadedness, blurred vision, loss of appetite, itching, stomach upset, headache, and ; weakness. Ann Emerg Med 16 (1987): 901-341. Bain PG, Egner W, Walker PR "Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage ." Bjornberg A, Gisslen H "Thiazides: A cause of necrotising vasculitis?" Fine SR, Lodha A, Zoneraich S, Mollura JL "Thiazide-induced pulmonary edema." West J Med 138 (1983): 101-248. Am J Clin Pathol 81 (1984): 791-477. Jones IG, Pickens PT "Diabetes mellitus following oral diuretics." Correspondence to David H. Ellison, Division of Nephrology and Hypertension, Oregon Health & Science University, 3314 SW US Veterans Hospital Rd, Portland, OR 97239. Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension." Diffey BL, Langtry J "Phototoxic potential of thiazide diuretics in normal subjects." Am J Surg 112 (1966): 97-10169. Clin Cardiol 18 (1995): 112-440. Side-effects are uncommon, as the dose needed to lower blood pressure is low. Significant reductions in the serum potassium (decreases of 0.5 mEq/L or more) have been observed in up to 50% of patients who are taking moderate doses of thiazide diuretics . Onset of symptoms can occur within minutes (range 10 to 150 minutes) of first exposure to the drug. During the 1970s, the first of several debates about unwanted consequences of thiazides arose. ), the Department of Veterans’ Affairs (Merit Review to D.H.E. Hypokalemia was deemed hazardous by many investigators; associations with ventricular arrhythmias were especially worrisome.Unlike loop diuretics, thiazides do not affect K transport directlySome observational studies have suggested that diuretic-induced hypokalemia may be associated with an increased incidence of arrhythmias,Although concern about hypokalemic arrhythmias from thiazide use continues, its preeminence has been replaced by concern about other metabolic adverse effects. Isr J Med Sci 25 (1989): 572-465. Delevett AF, Recalde M "Diuretic-induced renal colic." Their preliminary reportOnce again, mechanistic insight into the causes of diuretic-induced hyperglycemia might be gleaned from studies of individuals with inherited alterations in NCC; individuals with FHHt, who suffer from hyperkalemia, are typically treated with thiazide diuretics, but in this case the diuretics simply reduce the elevated potassium toward normal. However, they do indicate that it is not necessary to invoke direct effects on vascular smooth muscle to explain the vasodilatation that is observed during their use. A more direct test would be to determine whether thiazide diuretics reduce blood pressure in individuals who lack functional NCC (GS).When thiazides were introduced into clinical medicine, relatively high doses were used (≤150 mg/d of hydrochlorothiazide), and hypokalemia was common and severe. Am J Med 109 (2000): 429-3081. Grunwald MH, Halevy S, Livni E "Allergic vasculitis induced by hydrochlorothiazide: confirmation by mast cell degranulation test." Goodrich AL, Kohn SR "Hydrochlorothiazide-induced lupus erythematosus: a new variant?" Recently, Lifton et alThe presence of vasodilatation in individuals with GS argues that thiazide-induced vasodilation reflects whole-body autoregulation because of renal actions, although a component of drug-induced direct vasodilatation cannot be excluded. N Engl J Med 321 (1989): 868-7313. Ann Intern Med 133 (2000): 516-26Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Levay ID "Hydrochlorothiazide-induced pulmonary edema." There are different types of diuretics which work in different ways and thiazide diuretics are one type of diuretic.Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last?Coronavirus: what are asymptomatic and mild COVID-19?Coronavirus: what are moderate, severe and critical COVID-19?What are the differences between colds, flu and COVID-19?COVID-19: how to tell hay fever and coronavirus apartAre any coronavirus home remedies safe or effective?Is losing your sense of taste and smell a symptom of coronavirus?There are a number of thiazide diuretics - they include One of their effects is to make the kidneys pass out more fluid.