Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous. Avoid tanning booths and sunlamps. Use Older adults may be more sensitive to the side effects of this drug, especially dizziness, Some products that may interact with this drug include: Other medications can affect the removal of thioridazine from your body, which may affect how thioridazine works. However, it is expected that such co-administration would produce additive prolongation of the QTc interval and, thus, such use is contraindicated.Mellaril (thioridazine) is an antipsychotic used to manage schizophrenia. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD Although the exact mechanism of antipsychotics is unknown, scientists believe they may work by blocking the action of the neurotransmitter Mellaril should be used with caution with medications that depress the central nervous system and cause sedation or drowsiness such as:Combining alcohol with Mellaril also increases the risk of Thioridazine causes extrapyramidal side effects such as:In the recommended dosage ranges with Mellaril (thioridazine HCl) most side effects are mild and transient.These are voluntary reports of adverse events temporally associated with Mellaril (thioridazine hcl) that were received since marketing, and there may be no causal relationship between Mellaril (thioridazine hcl) use and these events: It should be noted that efficacy, indications, and untoward effects have varied with the different phenothiazines. The risk of this side effect is higher in women and older adults. Thioridazine Hydrochloride is the hydrochloride salt form of thioridazine, a piperidine phenothiazine derivative and a dopamine antagonist with antipsychotic property. Use: Patients with schizophrenia who failed to respond to treatment with other antipsychotic agents You may report side effects to FDA at 1-800-FDA-1088.In the recommended dosage ranges with thioridazine hydrochloride most side effects are mild and transient.The syndrome is characterized by involuntary choreoathetoid movements which variously involve the tongue, face, mouth, The syndrome may become clinically recognizable either during treatment, upon dosage reduction, or upon withdrawal of treatment. Select one or more newsletters to continue. Thioridazine rarely has caused very serious (possibly fatal) irregular heartbeat (QT prolongation in the There may be a slightly increased risk of serious, possibly fatal side effects (such as Dosage is based on your medical condition and response to therapy. Signs and symptoms of abuse or trauma include appetite or mood changes, alcohol and/or drug abuse, difficulty sleeping, and anger. The longer you take thioridazine, the more likely you are to develop this movement disorder. This may be done over time. 4,5 Subsequent studies revealed that these drugs extended the QT interval by inhibiting the rapid component of the delayed rectifier K + current (I Kr) that is largely but not completely recapitulated by the human ether-a-go-go related gene … Learn more about the challenges of mental illness with the Schizophrenia Quiz.About 5 million children and adolescents in the U.S. suffer from a serious mental illness such as eating disorders, anxiety disorders, disruptive behavior disorders, pervasive development disorders, elimination disorders, learning disorders, schizophrenia, tic disorders, and mood disorders.