Types, Symptoms, Diagnosis and Care. Online Mendelian Inheritance in Man (OMIM). Other symptoms may include inflammation of the lungs (interstitial pneumonitis), difficulty breathing, coughing, painfully cold fingers in response to cold (Raynaud’s phenomenon), digestive problems, heart irregularities, and kidney failure. Hemorrhage includes hematoma, and vaginal and urethral hemorrhage. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Scleroderma Clinical Trials Consortium. The exact cause of scleroderma is unknown.The early symptoms of scleroderma vary considerably. Verywell Health is your destination for reliable, understandable, and credible health information and expert advice that always keeps why you came to us in mind. Arthritis occurs in almost every case of mixed connective tissue disease, but rarely results in deformities similar to those seen in rheumatoid arthritis. AAOHN J. These areas of hardness are widespread and typically appear on both sides of the body. Philadelphia, PA. 2003:33-34.Beers MH, Berkow R, eds. These side effects may go away during treatment as your body adjusts to the medicine. About 50 percent of people with lupus exhibit a classic red “butterfly” rash across the bridge of the nose and cheeks. Researchers believe that several factors interact to produce scleroderma. Please note that NORD provides this information for the benefit of the rare disease community. Clin Exp Dermatol. Some types affect certain, specific parts of the body, while other types can affect the whole body and internal organs (systemic). The major symptom of this disorder is a dramatic stark white pallor of the affected fingers and toes when exposed to cold, although a blue or red color may also be present from time to time. Consider an alternative anticoagulant if apixaban treatment is discontinued for any reason other than pathological bleeding or treatment completion. 2003;51:353-57.Clin Exp Rheumatol. "Product Information. Gastrointestinal dysmotility refers to problems with the muscular contractions of the stomach wall that are necessary to move or squeeze contents forward. Other vasodilators or beta-adrenergic blockers also have been used with some success. Seven (7) Review Articles.Acorn S, Joachim G, Wach JE. 2003;15.748-790. Entry Number; 181750: Last Edit Date; 3/17/2004.Scleroderma. (For more information, choose “Polymyositis” and “Dermatomyositis” as your search terms in the Rare Disease Database. Eliquis (apixaban)." A skin rash can signal many things, but it's often the result of an allergy.Mysterious rashes send millions to the doctor each year. Bristol-Myers Squibb Canada Inc, Montreal, IN. Lippincott Williams & Wilkins. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Microchimerism and scleroderma: an update. Vasodilators, including the drugs nifedipine (Procardia), reserpine (Serpasil), guanethidine (Ismelin), phenoxybenzamine (Dibenzyline), nicotinic acid, diltiazem, verapamil, and/or prazosin (Minipress) may be prescribed.In rare cases of scleroderma, abnormal accumulation of calcium salts under the skin and in other organs (calcinosis) may require surgical intervention. Pulmonary hypertension occurs in some individuals with scleroderma. The purpose is to identify and study specific antibodies that are often found in the blood of people affected by scleroderma. Individuals may print one hard copy of an individual disease for personal use, provided that content is unmodified and includes NORD’s copyright.To search for patient organizations and other pages related to this topic, use the Advanced Search function at the top right corner of the page.NORD strives to open new assistance programs as funding allows. Some of the dosage forms listed on this page may not apply to the brand name Topamax.. Other early symptoms may include fever, swollen glands, loss of appetite, weight loss, headaches, loss of hair, and swelling due to fluid retention. )Treatment of scleroderma is symptomatic and supportive. 2003;42:598-606.Artlett CM. Curr Rhematol Rep. 2003;5:154-59.Valentini G, Black C. Systemic sclerosis. Occasionally, joint pain and tenderness also occur. Affected individuals may also exhibit telangiectasia, meaning the appearance of small blood vessels near the surface of the skin. (For more information, choose “Raynaud” and “Pulmonary Hypertension” as your search terms in the Rare Disease Database. About 50 percent of people with lupus exhibit a classic red “butterfly” rash across the bridge of the nose and cheeks. Many common medications cause this reaction in some people. In Summary. Dr. Donald Colantino answered. Consider the benefits and risks of neuraxial intervention in patients who are or need to be anticoagulated.Along with its needed effects, apixaban may cause some unwanted effects.