Lever wrote a letter outlining his concerns to the Food and Drug Administration in 2012, and this year, he traveled to Washington to try to get the attention of Congress.Dr. Prior to initiation of TOPROL-XL, stabilize the dose of other heart failure drug therapy. The dose of TOPROL-XL should not be increased until symptoms of worsening heart failure have been stabilized.TOPROL-XL is an extended-release tablet intended for once daily administration. I was on the brand name Toprol XL for about 5 years and never had a problem.-200mg. When he switched them back to the brand — or to another generic — the symptoms disappeared, he said. The usual initial dosage is 100 mg daily, given in a single dose. Individualize the dosage of TOPROL-XL. What form(s) does this medication come in? There were dissolution problems. Following is a list of possible medication recalls, market withdrawals, alerts and warnings. 2. In other words, it didn’t dissolve properly in a test solution. We comply with the HONcode standard for trustworthy health information - Dosages above 400 mg per day have not been studied. Individualize the dosage of TOPROL-XL. Initial difficulty with titration should not preclude later attempts to introduce TOPROL-XL. Lever is feeling a sort of sad vindication. If a meal is skipped, skip the dose. Earlier this year the agency put a call out to researchers to investigate the efficacy of generic versions of metoprolol succinate, which is best known by AstraZeneca’s brand name, Toprol XLEven as the agency has stepped up its scrutiny of generics, however, it has maintained its long-held position that generic drugs are generally as safe and effective as the brand-name versions.Dr. Adults: The usual initial dosage is 25 to 100 mg daily in a single dose. In 2008 the FDA warned Sandoz that its formulation of metoprolol succinate had not been properly validated. persistent cough lasts more than one week, tends to recur, or is accompanied by fever, rash or persistent headache. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. If selected for treatment, the recommended starting dose of TOPROL-XL is 1.0 mg/kg once daily, but the maximum initial dose should not exceed 50 mg once daily. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy. Therefore, Starlix should be used with caution in patients with moderate-to-severe liver disease (see PRECAUTIONS, Hepatic Impairment).This website is intended for informational and entertainment purposes only and is not intended to replace any professional medical advice.This field is for validation purposes and should be left unchanged. “There’s been this assumption that one generic is the same as another. Select one or more newsletters to continue. The recall includes only the 25 mg tablet, 100-count bottle. Individualize the dosage of TOPROL-XL. Dosage should be adjusted according to blood pressure response. TOPROL-XL is an extended-release tablet intended for once daily administration. The FDA has just announced that a maker of generic Toprol XL will have to recall 109,744 bottles of metoprolol succinate. It's a drug called a beta-blocker. Titration may be needed in some patients.TOPROL-XL tablets are scored and can be divided; however, do not crush or chew the whole or half tablet. If patients experience symptomatic bradycardia, reduce the dose of TOPROL-XL.