Possible driving impairment is also seen with eszopiclone and the recommendation is to start with 1 mg and to titrate slowly to 2 to 3 mg, if necessary, in the absence of side effects.A more recent agent, ramelteon is a melatonin receptor agonist. Select one or more newsletters to continue. These agents have a higher index of safety but can also be associated with daytime problems such as driving impairment and memory difficulties, especially in women, possibly because of slower metabolism. Finally, watch patients carefully and see them frequently to monitor for emergence of any adverse effects. Its main potential adverse effect is daytime sedation.The bottom line is that all agents have potential for daytime sedation as well as other adverse effects (eg, memory detriment, driving impairment). This study provides common interactions between Micardis and Melatonin, and groups them by gender and age (0-60+). Trazodone is an antidepressant that may also be used to treat insomnia. Insomnia is a frequently encountered problem that at any given time affects up to 20% of the general population. It is not a scheduled drug so it may be useful for patients with a history of substance abuse. The most commonly used antidepressant is trazodone. Low-dose doxepin (3 to 6 mg) is a selective agent at the histaminic receptor site; it is indicated for sleep maintenance problems. Trazodone was developed in Italy in the 1960s as an antidepressant medication. Disorders that can produce sedation and respiratory suppression (eg, COPD, sleep apnea) should also be treated first before starting a patient on sleep medications. These include antidepressants, antipsychotics, and some anti-epilepsy compounds. How well does it work on average to improve falling asleep or sleeping more at night? Summary: Drug interactions are reported among people who take Micardis and Melatonin together. However, it is associated with rapid development of tolerance and because of its long half-life, it is associated with daytime sedation, and in rare cases, risk of priapism and drug-drug interactions that can result in serotonin syndrome.Low-dose antipsychotics have also been used. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. In addition, to avoid exacerbating problems of abuse, caution is needed in the case of scheduled medications, especially for patients with a history of substance abuse. However, the long half-life of these agents may produce daytime sedation, motoring coordination problems, and memory difficulties.Although not specifically indicated for insomnia problems, some prescribed agents may have a sedating effect. Speak to your doctor about how drug interactions should be managed.Common medications that may interact with trazodone include:Avoid drinking alcohol or taking illegal or recreational drugs while taking trazodone.Note that this list is not all-inclusive and includes only common medications that may interact with trazodone You should refer to the prescribing information for trazodone for a complete list of interactions.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trazodone only for the indication prescribed.Copyright 1996-2020 Drugs.com. This increases levels of serotonin in the nerve synapse (the space between two nerves). Available for Android and iOS devices. What are the common side effects? For a complete list of all side effects, Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Why Are Dementia Patients Getting Risky Psychiatric Drugs? In this video, Dr Karl Doghramji describes the various agents available for managing insomnia and discusses the adverse effects associated with over-the-counter, nutraceutical, and prescription sleep aids. However, it may cause withdrawal symptoms on discontinuation.Medicines that interact with trazodone may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with trazodone. Orexin receptors are important in the orderly transition between wakefulness and sleep and vice versa. Revision date: November 5, 2019.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.