It must have the ability to get into the body and that's scary . That's when I found this site. I stopped the tretinoin for a week now and my skin is getting better, my eyes, I feel, are getting a little better. Maybe in 1 month I will only use it once a week, as I love what it does for my skin but I think using it every night was just too much for me. too close to my thyroid. I'm going back to the doc and stopped using my Epiduo gel about a week ago. I've been cycling through using various retinoids for adult acne for the past year and have had horrible hair shedding since late Nov 2015. Of 15 pediatric patients (age range: 1 to 16 years) treated with Tretinoin Capsules, the incidence of complete remission was 67%. 1999 Sep;20(6):301-8. doi: 10.1002/(sici)1099-081x(199909)20:6<301::aid-bdd189>3.0.co;2-5.Olsen EA, Katz HI, Levine N, Shupack J, Billys MM, Prawer S, Gold J, Stiller M, Lufrano L, Thorne EG.J Am Acad Dermatol. It increases sun sensitivity, so you need to use it with sunscreen. Select one or more newsletters to continue. This med requires a prescription in any case. Four specialists and twenty thousand dollars later, I was sent to the head onocologist at a major hospital. I even thought I had gotten the No No! Well he did boo hoo this and told me it was perfectly safe and that so few people have any systems, thus this has not been an issue that we read about. 11 years without a polyp. Comparison of these in vitro and in vivo results for absorption through rat skin indicates that the 24-h in vitro receptor fluid value accurately estimated 24-h in vivo systemic absorption. I started using the gel in the beginning of February and started experiencing a rapid heart rate and chest pain. I'm 46 now. Topical application of tretinoin at doses used in acne unlikely induces systemic effects. I am going to discontinue the Retin-A & multivitamin until it's out of my system. I immediately stopped retin-a and literally with in a few days I was feeling fine. I don't recall when, two-three years prior?, I noticed the blurry eyes, but they got unbearable with the .1%. Since the second time I used it (a pea sized amount on my face after moisturiser, avoiding my eyes) I started to get severe headaches, dry eyes, joint pain and swelling in my fingers and wrists and fever. Supportive care appropriate for APL patients, eg, prophylaxis for bleeding, prompt therapy for infection, should be maintained during therapy with Tretinoin Capsules.There is a risk of thrombosis (both venous and arterial) which may involve any organ system, during the first month of treatment (see The ability to drive or operate machinery might be impaired in patients treated with Tretinoin Capsules, particularly if they are experiencing dizziness or severe headache.Microdosed progesterone preparations (“minipill”) may be an inadequate method of contraception during treatment with Tretinoin Capsules.The patient’s hematologic profile, coagulation profile, liver function test results, and triglyceride and cholesterol levels should be monitored frequently.Limited clinical data on potential drug interactions are available.As Tretinoin Capsules are metabolized by the hepatic P450 system, there is a potential for alteration of pharmacokinetics parameters in patients administered concomitant medications that are also inducers or inhibitors of this system. Tretinoin 0.1I was using a tiny amount of Tretinoin on my face for approximately two months. Sucks because I am 48 and do not look it. My skin never looked better, melasma decreased as well as fine lines. The response rate of other AML subtypes to Tretinoin Capsules has not been demonstrated; therefore, patients who lack the genetic marker should be considered for alternative treatment.In up to 25% of patients with APL treated with Tretinoin Capsules, a syndrome occurs which can be fatal (see boxed Retinoids, including Tretinoin Capsules, have been associated with pseudotumor cerebri (benign intracranial hypertension), especially in pediatric patients. No headaches no dizziness and I didn't even need the glasses I was prescribed. Junko sorry to hear of your problems and glad you found out the source. These effects on the cells are controlled by receptors on the nucleus of each cell (nuclear receptors).The toxicity of retinoids and, in particular, tretinoin is well known – and has been understood by scientists for nearly 20 years. Can the retinol be absorbed directly into the thyroid topically?I think this deserves a bit of an update and correction. I think Retin a is not for every one despite it benefitsI started using Retin A last year. I changed my diet and sleep routines but it wasn't getting better. Dear doctors, I am prescribed 2% hydroquinone and am told to use it together with Retin A.