Secondary outcomes for the neonate included birth weight, infant death, gestational age at birth, congenital malformations, Apgar score less than seven at five minutes, vitamin K deficiency bleeding or haemorrhagic disease of the newborn, respiratory distress syndrome, chronic lung disease or bronchopulmonary asthma, periventricular haemorrhage, bacterial sepsis, necrotising enterocolitis, retinopathy of prematurity, peripheral neuropathy, disability at childhood follow-up (cerebral palsy, intellectual disability, hearing or visual impairment), poor childhood growth, admission to neonatal intensive care unit, duration of mechanical ventilation, length of stay in hospital, development, and special needs after discharge.Twenty-one randomized controlled trials, enrolling 22,129 women, were included in this reviewThe overall methodological quality of the included trials was fair, with several of the largest trials considered to be at low risk of bias contributing much of the data to analyses. Contact your healthcare professional (e.g. Effects of allopurinol on theophylline metabolism and clearance. This information is generalized and not intended as specific medical advice. While vitamin E supplementation reduced the risk of placental abruption, an increased risk of term PROM and the side effect abdominal pain was also found among women receiving vitamin E.Further research into the effect of vitamin E on the risk of placental abruption is warranted. They may already be aware of this drug interaction and may be monitoring you for it. The dose of your medicines may need adjusting. To evaluate the effects of vitamin E supplementation during pregnancy on pregnancy outcomes, adverse events, side effects and the use of health services doctor or pharmacist) as soon as possible about taking these two medicines together. It is a summary of findings and some data from the systematic review may therefore not be included. High doses of allopurinol taken for more than two weeks may increase the chance for harmful effects. e) Drug and additional vitamin E restriction . Notes. Clin Pharmacol Ther 1979 Nov; 26(5):660-7. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. This document has been produced by the World Health Organization. Do not start, stop, or change the dosage of any medicine without checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. Pages 6 Ratings 100% (1) 1 out of 1 people found this document helpful; This preview shows page 3 - 5 out of 6 pages. Data from the three identified trials in which vitamin E was given alone could not be included in analyses, and thus treatment effects may not be due to vitamin E as the majority of other trials also provided vitamin C. Few trials were conducted in women known to have inadequate intakes of vitamin E, and thus the findings may not be generalizable to all populations.The evidence reviewed here does not support the routine use of vitamin E in pregnancy for the prevention of fetal or neonatal death, preterm birth, preeclampsia, or intrauterine growth restriction for women with or without a high risk of adverse pregnancy outcomes. While some research suggests that vitamin E prevents the risk of asthma and improves breathing in children, other research doesn't show this effect. The role of vitamin E in asthma is unclear. Vitamin E Herbs ginseng St Johns wort Corticosteroids NSAIDS Allopurinol.