Blood tests. The following variables were obtained by the chart review: age, sex, date of liver biopsy, titers of antinuclear antibodies, smooth muscle antibodies, liver kidney microsomal, antimitochondrial antibodies, antinuclear cytoplasmic antibodies, IgG, gammaglobulins, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, albumin, and international normalized ratio at baseline. Cases of Graves' disease and Hashimoto's thyroiditis, following hepatitis B vaccine have been reported to the … Information on whether immunosuppressive therapy was discontinued during follow‐up and the results of the discontinuation were obtained. 1, 2 Reactive metabolites created through hepatic metabolism of some drugs have been shown to bind to cellular proteins such as cytochrome P450. Tests and procedures used to diagnose autoimmune hepatitis include: 1. It is interesting to note that drug-metabolizing enzymes of phase I and phase II are common targets of autoimmunity in idiopathic autoimmune hepatitis and viral hepatitis.Nowadays, more than 900 drugs, toxins, and herbal remedies have been reported to cause liver injury. If there is too much medicine in your blood for your liver to break down, your liver can become badly damaged. Painkillers and fever reducers that contain acetaminophen are a common cause of liver injury, particularly when taken in doses greater than those recommended. Socio-economic, psychological, and cultural issues can influence the type, frequency, and duration of treatment, and certain diseases with propensities for a particular gender or age group may skew the perception of risk. Taken together, our results suggest that DIAIH is a distinct phenomenon, and a trial of withdrawal of immunosuppression should be undertaken in these patients.Previous literature on DIAIH consist only of case reports and small case series. Only patients with available clinical and biochemical components of the new simplified criteria at baseline were included.Furthermore, patients with a diagnosis of primary biliary cirrhosis and primary sclerosing cholangitis were excluded, as were patients with clinical suspicion of overlap syndromes (AIH/primary biliary cirrhosis and AIH/primary sclerosing cholangitis).A retrospective review was performed on patients fulfilling the inclusion criteria. Autoimmune hepatitis is liver inflammation that occurs when your body's immune system turns against liver cells. Azathioprine and 6-mercaptopurine can lower the number of your white blood cells and raise your chances of getting cancer.Autoimmune Hepatitis Association: "What is Autoimmune Hepatitis? Department of Internal Medicine, Section of Gastroenterology and Hepatology, Landspitali University Hospital, Reykjavik, IcelandDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDepartment of Radiology, Mayo Clinic Rochester, Rochester, MNDepartment of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDepartment of Internal Medicine, Section of Gastroenterology and Hepatology, Landspitali University Hospital, Reykjavik, IcelandDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDepartment of Radiology, Mayo Clinic Rochester, Rochester, MNDepartment of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNDivision of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MNUse the link below to share a full-text version of this article with your friends and colleagues. 2. Drug‐induced autoimmune hepatitis (DIAIH) has been reported to be caused by several drugs. Overall, 560 cases were excluded because of an earlier diagnosis of AIH outside the Mayo Clinic, and many of these patients were on treatment when first seen at the Mayo Clinic. Drug-induced autoimmune liver disease is a variant of Autoimmune Hepatitis which has not been defined in detail in the literatures.