They also looked at prescribing information for recently approved drugs in Canada. For most medications, orange juice, apple juice, or grape juice can be consumed instead of grapefruit juice without any concern for an interaction. However, orange or apple juice can cause an interaction with fexofenadine (Allegra) and aliskerin (Tekturna).You should use caution when eating anything made with the seville orange (often used in marmalades), the pomelo (a citrus fruit with a similar flavor to grapefruit but less tart), and limes. Please check with the appropriate physician regarding health questions and concerns. While grapefruit is a go-to healthy snack for many people, it contains a chemical called furanocoumarins which prevents enzymes in the body called CYP3A from breaking down certain types of statins. This no-sugar meal plan will help you kick the craving with healthy whole foods and get back on track with healthy habits. When taken with medicine, grapefruit can delay, decrease, or enhance absorption of certain drugs; as a result, the patient does not receive the prescribed dosage of the medication. EatingWell may receive compensation for some links to products and services on this website. This can cause life-threatening muscle damage called “Grapefruit and grapefruit products may interact with a broad class of medications ranging from cardiovascular to hormonal drugs,” says Tara Narula, MD, the associate director of cardiac care at Lenox Hill Hospital in New York City. Available for Android and iOS devices. Most types of blood pressure medicines are not affected by grapefruit. However, the following four blood pressure medications should be used … These fruits also contain furanocoumarins and may cause the same interactions as grapefruit. How to Eat Healthy Incorporating this food may help. Holly Pevzner With some drugs, just one serving of grapefruit can make it seem like a person is taking multiple doses of the drug.This interaction can occur even if grapefruit is eaten many hours before taking the medication. A juicy grapefruit is both refreshing and healthy, but if you're taking certain prescription medications, think twice before digging into one. this link is to an external site that may or may not meet accessibility guidelines. Steer clear of drug interactions with grapefruit by checking the list of additional medications that raise interaction risk.A juicy grapefruit is both refreshing and healthy, but if you're taking certain prescription medications, think twice before digging into one. So, even if you take a medicine that is given only once per day, grapefruit and grapefruit juice should still be avoided for the entire treatment period. This equates to more than six new potentially risky drugs a year.Here’s what happens: Grapefruit contains furanocoumarins, which block an enzyme that normally breaks down certain medications in the body. Statins The effects of grapefruit juice on certain medications can last for over 24 hours. New additions include solifenacin and tamsulosin (VESIcare, Flomax) for urinary issues and eplerenone (Inspra) for hypertension. Don't take these interactions lightly. Normally, an enzyme in the small intestine regulates how much of the drug is absorbed. New List of Prescription Drug & Medication Interactions with Grapefruit and Grapefruit Juice Steer clear of drug interactions with grapefruit by checking the list of additional medications that raise interaction risk. Nov. 27, 2012 -- The number of drugs that can be risky when taken with grapefruit is on the rise, largely due to the influx of new medications and chemical formulations, a new study shows.As it stands, there are now more than 85 drugs that may interact with grapefruit. Home Grapefruit is a delicious citrus fruit with many health benefits.Medications are processed in your liver and small intestine by a specialized group of proteins called CYPs break down medications, reducing the blood levels of many of them.Grapefruit and a few of its close relatives, such as Seville oranges, tangelos, pomelos and Minneolas, contain a class of chemicals called Furanocoumarins disrupt the normal function of CYPs.