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An oral dose of 7.5 mg of midazolam was ingested after fluconazole/placebo. About three out of every four adult women will have at least one vaginal yeast infection during their life.Some medicines and medical conditions can increase your chance of getting a yeast infection.
There is an inverse relationship between the elimination half-life and creatinine clearance. AIDS patients are more prone to the development of severe cutaneous reactions to many medicinal products. The incidence of abnormally elevated serum transaminases was greater in patients taking fluconazole concomitantly with one or more of the following medications: rifampin, phenytoin, isoniazid, valproic acid, or oral sulfonylurea hypoglycemic agents.In addition, the following adverse events have occurred during post-marketing experience.The pattern and incidence of adverse events and laboratory abnormalities recorded during pediatric clinical trials are comparable to those seen in adults.In Phase II/III clinical trials conducted in the United States and in Europe, 577 pediatric patients, ages 1 day to 17 years were treated with fluconazole at doses up to 15 mg/kg/day for up to 1,616 days. The overall incidence of side effects possibly related to fluconazole was 26%. Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a powder for oral suspension.Fluconazole is designated chemically as [α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1-H-1, 2, 4- triazole-1-ethanol] with a molecular formula of CFluconazole USP is a white or almost white powder which is freely soluble in methanol, soluble in alcohol and acetone, sparingly soluble in isopropanol and in chloroform, slightly soluble in water, very slightly soluble in toluene.Fluconazole for Oral Suspension, USP is available for oral administration containing either 350 mg or 1400 mg of fluconazole, USP and the following inactive ingredients: citric acid anhydrous, natural orange flavor, silicon dioxide, sodium benzoate, sodium citrate, sucrose, titanium dioxide, and xanthan gum. [See USP Controlled Room Temperature.] Similarly, the half-life was 73.6 hours, which decreased with time to a mean of 53.2 hours six days later and 46.6 hours 12 days later.A pharmacokinetic study was conducted in 22 subjects, 65 years of age or older receiving a single 50 mg oral dose of fluconazole. Discussion in 'lasix kidney stones' started by dvu-v, 19-Jun-2020. Do not use fluconazole for a condition for which it was not prescribed.
In patients with fungal meningitis, fluconazole concentrations in the cerebrospinal fluid (CSF) are approximately 80% of the corresponding plasma concentrations.A single oral 150 mg dose of fluconazole administered to 27 patients penetrated into vaginal tissue, resulting in tissue: plasma ratios ranging from 0.94 to 1.14 over the first 48 hours following dosing.A single oral 150 mg dose of fluconazole administered to 14 patients penetrated into vaginal fluid, resulting in fluid: plasma ratios ranging from 0.36 to 0.71 over the first 72 hours following dosing.In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. These findings are not inconsistent with the natural history of tinea capitis without therapy.The pharmacokinetic properties of fluconazole are similar following its oral or intravenous administration. Fluconazole is administered as a single daily dose each day.The pharmacokinetics of fluconazole has not been studied in children with renal insufficiency.