Upper gastrointestinal tract bleeding was observed in 4.1 times more frequently in patients receiving sertraline (the active ingredient contained in Zoloft) In clinical trials in children and adolescents aged 6 to 17 years with major depressive disorder diarrhea, vomiting, and dry mouth were reported at a frequency of at least 2% and at least twice that of placebo.The results of one study appear to indicate that treatment with In clinical trials in children and adolescents aged 6 to 17 years with major depressive disorder, anorexia was reported at a frequency of at least 2% and at least twice that of placebo. You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Two cases of breast discomfort and enlargement without galactorrhea have also been reported.Case reports have suggested that sertraline, like other serotonin- specific reuptake inhibitors, may induce the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Cerner Multum, Inc. "UK Summary of Product Characteristics." Elderly patients may experience impaired thinking, judgment, and motor coordination.People who drive or operate heavy machinery for a living should avoid mixing these drugs as well, as the combination can affect mental alertness. Why Are Dementia Patients Getting Risky Psychiatric Drugs? Suicide ideation was reported by 3 sertraline-treated patients and no placebo-treated patients; however the difference was not statistically significant.Mania, affect lability were also commonly reported in controlled trials in pediatric patients.In a 12-week placebo-controlled study in pediatric patients with OCD, side effects observed at an incidence of at least 5% and at a statistically significant increased level for sertraline (the active ingredient contained in Zoloft) compared with placebo were headache (in 6 to 12 year olds) and tremor (in 13 to 17 year olds). Quitting cold turkey can lead to withdrawal symptoms including heightened depression and even suicidal thoughts, and changing or abandoning treatment might not be the best course of action for every user.Despite the potential dangers, there are few reports of major adverse interactions stemming from marijuana and Zoloft use. Suicide attempt was reported in the same number of patients in the sertraline (2 out of 189) and placebo (2 out of 184) groups. Reply Most users can manage both drugs in moderation without experiencing painful side effects, and in fact the reason why SSRIs are favored by physicians is because they tend to get along well with other drugs.The biggest concern isn’t the possibility of side effects. By increasing serotonin production, Zoloft and similar drugs work to counteract depression.In order to understand the adverse reactions that can occur when mixing sertraline with marijuana, you first need to understand the side effects that can occur with Zoloft alone:These side effects vary from person to person, but they may be exacerbated in some cases by cannabis use.Combining the drugs may promote or worsen the sertraline side effects listed above. The most significant reason to avoid mixing marijuana and SSRIs is that it puts your treatment at a disadvantage. The recommended starting ZOLOFT dosage in adult women with PMDD is 50 mg per day. Serotonin is a neurotransmitter that’s sometimes referred to as “the happy chemical” or “the feel-good chemical” because it’s associated with feelings of well-being. 2. The following information is NOT intended to endorse any particular medication. This can happen because cannabis inhibits certain enzymes in the liver that metabolize SSRIs.