oral olanzapine (doses ≥2.5 mg) reported with an incidence of 2% or more
asymptomatic increases in ALT, AST, and GGT. times ULN) were observed in 5% (77/1426) of patients exposed to olanzapine
Nausea and dry mouth have been reported to be dose related. at anytime, were observed in laboratory analytes compared to placebo: elevated
or bipolar I mania was 6% for intramuscular olanzapine for injection and 3% for
patients, compared to 0.3% (4/1196) of placebo-treated patients. Dystonic symptoms include: spasm of the neck muscles, sometimes
varied greatly and included (in overlapping categories) open-label and
following baseline evaluation. In a single 8-week randomized,
FDA Prescribing Information
Consequently, it is not possible to provide a meaningful
infrequently (<1%) with olanzapine use.Following is a list of treatment-emergent adverse
Most important fact about Zyprexa At the start of Zyprexa therapy, the drug can cause extreme low blood pressure, increased heart rate, dizziness, and, in rare cases, a tendency to faint when first standing up. Haloperidol is an antipsychotic medication used for treating Olanzapine is an atypical antipsychotic used to treat The most common side effects associated with Haldol are:Haldol also may cause abnormal heart beats, sudden death, Several disorders of movement also may occur with olanzapine, for example, extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes). ZYPREXA INTRAMUSCULAR prescription and dosage sizes information for physicians and healthcare professionals. ★ Zyprexa Helps Chronic Pain - Pain Gone in 7 Days or Less! Women who experience an increase in prolactin may develop breast milk and miss their periods.Because the development of breast milk can be frightening for a woman who is not pregnant, and the development of breast tissue can be troubling for a man, anyone suffering from these side effects should call their doctor as soon as possible.Stomach problems are a common side effect of many medications, and Zyprexa is no different. and (2) intramuscular olanzapine for injection in agitated patients with
also associated with increases in serum prolactin [see From an analysis of the
reactions are those occurring in at least 1/100 patients; infrequent adverse
Oral formulations: Very common (10% or more): Dry mouth (up to 32%), constipation (up to 11%), dyspepsia (up to 11%) in heart rate compared to placebo (adults: +2.4 beats per minute vs no change
at last follow-up in the majority of patients who either continued treatment
Reactions listed
observed in 4% (8/192) of olanzapine-treated patients, compared to 1% (1/109)
associated with the combination of olanzapine and lithium or valproate
FDA. In general, an elevated
anaphylactoid reaction, angioedema, pruritus or urticaria), cholestatic or
Zyprexa (olanzapine)." Olanzapine is also used to treat acute manic episodes associated with bipolar I disorder and some types of depression.What is schizophrenia? Akathisia most commonly occurred with oral doses of 15 mg/day; akathisia events included akathisia and hyperkinesia.Dyskinetic events included buccoglossal syndrome, choreoathetosis, dyskinesia, and tardive dyskinesia.Parkinsonism/parkinsonism events most commonly occurred with oral doses of 15 mg/day and included akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, masked facies, and tremor.Sedation most commonly occurred in adolescent patients given oral doses at least 2.5 mg/day over 3 weeks; sedation included Somnolence and tremor most commonly occurred with oral doses given with Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents, including olanzapine (the active ingredient contained in Zyprexa) for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug treated patient than in the placebo treated patient. Similarly, the
In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal (ULN) in approximately 30% of patients who had normal baseline prolactin values. and (6) 722 patients who participated in intramuscular olanzapine for injection
We comply with the HONcode standard for trustworthy health information - who participated in the acute phase of placebo-controlled combination trials.For specific information about the adverse reactions
MedDRA and COSTART Dictionary terminology has been used to classify reported
percent, of treatment-emergent adverse reactions that occurred in 1% or more of
The final section lists severe rare side effects that must be reported to your doctor immediately. 2.5 to 20 mg/day).The following table enumerates the percentage of patients
patients treated with oral olanzapine (doses ≥2.5 mg/day) and with
Intramuscular
Also included below is information from
This
With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.Bipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Since Zyprexa makes many people drowsy, you might find that taking it at bedtime works best.While taking Zyprexa, try to avoid other medications that induce drowsiness.