Plasma concentrations following oral administration are much lower than those following intramuscular injection, and are subject to wide inter-subject variation. Prochlorperazine has anti-emetic, anti-pruritic, serotonin-blocking, and weak antihistamine properties and slight ganglion-blocking activity. If persistent or life threatening, appropriate anti-arrhythmic therapy may be considered. Pharmacological induction of emesis is unlikely to be of any use. • Hypotension, usually postural, commonly occurs. There is a possible pharmacokinetic interaction between inhibitors of CYP2D6, such as phenothiazines, and CYP2D6 substrates. (ii) Surface printed 20µm hard temper aluminium foil with 5-6g/M² PVC and PVdC compatible heat seal lacquer on the reverse side.Pack sizes: 28, 30, 56, 60, 84, 90, 100, 112, 120, 168, 180, 250s, 500s, 1000s.Product may also be supplied in bulk packs, for reassembly purposes only, in polybags contained in tins, skillets or polybuckets filled with suitable cushioning material.To bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Signs of autonomic dysfunction, such as sweating and arterial instability, may precede the onset of hyperthermia and serve as early warning signs. The occurrence of unexplained infections or fever may be evidence of blood dyscrasia (see section 4.8), and requires immediate haematological investigation.It is imperative that treatment be discontinued in the event of unexplained fever, as this may be a sign of neuroleptic malignant syndrome (pallor, hyperthermia, autonomic dysfunction, altered consciousness, muscle rigidity). Login to reply the answers Post; How do you think about the answers? If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. It is also extensively metabolised in the liver and is excreted in the urine and bile. • Hyperprolactinaemia which may result in galactorrhoea, gynaecomastia, amenorrhoea and impotence. (See section 4.9).The CNS depressant actions of neuroleptic agents may be intensified (additively) by alcohol, barbiturates and other sedatives. Relapse may also occur, and the emergence of extrapyramidal reactions has been reported. 0 0 0. Compazine (prochlorperazine): “I’m sorry you all have gone through this but at least I feel I am not alone! 40 years experience General Practice. 3 thanks. • Cases of venous thromboembolism, including cases of pulmonary embolism and cases of deep vein thrombosis have been reported with antipsychotic drugs – Frequency unknown Dantrolene sodium may be tried.Pharmacotherapeutic group: Phenothiazines with piperazine structureProchlorperazine has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and weaker anti-muscarinic properties. It should be avoided in patients known to be hypersensitive to phenothiazines or with a history of narrow angle glaucoma or agranulocytosis.Close monitoring is required in patients with epilepsy or a history of seizures, as phenothiazines may lower the seizure threshold.As agranulocytosis has been reported, regular monitoring of the complete blood count is recommended. Acute migraine. 3–6 mg twice daily, tablets to be placed high between upper lip and gum and left to dissolve. Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Plasma half-life is reported to be only a few hours but elimination of the metabolites may be very prolonged. Other medicinal products and other handling9 the response to neuroleptic treatment may be seen:,. Persistent or life threatening, appropriate anti-arrhythmic therapy may be considered early signs. 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