The brain is rich in estrogen receptors and contains aromatase, 26 and it has been suggested that estrogen-replacement therapy is associated with a reduced risk of Alzheimer's disease. Aromatase Inhibitors and Risk of Coronary Heart Disease and Stroke In the Arimidex, Tamoxifen, Alone or in Combination trial comparing tamoxifen with anastrozole, significantly fewer venous thromboembolic events and endometrial cancers were reported in the anastrozole group at 68 months of median fol- low-up. Register for 3 FREE subscriber-only articles each month. ScienceDirect ® is a registered trademark of Elsevier B.V.Coronary Heart Disease and Stroke with Aromatase Inhibitor, Tamoxifen, and Menopausal Hormone Therapy UseCopyright © 2006 Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. 3 In addition, ischemic cerebral vascular events were seen in fewer … By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. This enzyme is highly expressed in various brain regions across species, with some inter-species variation in terms of regional brain expression. Results from the Women's Health Initiative randomized clinical trials of hormone therapy provide the clinical context for interpreting tamoxifen and aromatase inhibitor (AI) findings regarding coronary heart disease (CHD) and stroke.
The first 5 years of hormonal therapy were either tamoxifen, an aromatase inhibitor, or tamoxifen then an aromatase inhibitor. 6. However, new aromatase inhibitors that are many times more potent and specific than the first such agent, aminoglutethimide, are changing the management of breast cancer in postmenopausal women. J Pineal Res. Current but limited evidence suggests that AIs have a modest increase or no effect on CHD as a class or as individual agents compared with tamoxifen. This review discusses the role of aromatase inhibitors such as letrozole, anastrozole, and exemestane in the treatment of breast cancer. 2006;66(11):5960-5967. Aromatase Inhibitor–Induced Musculoskeletal Symptoms. Cancer Res. Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.It is CYP19A1, a member of the cytochrome P450 superfamily (EC 1.14.14.1), which are monooxygenases that catalyze many reactions involved in steroidogenesis.In particular, aromatase is responsible for the aromatization of androgens into estrogens.
Are you a member of an institution such as a university or hospital?We are indebted to Alison Norton for invaluable secretarial and editorial assistance and advice and to Dr. Alistair Ring for helpful comments.From the Royal Marsden Hospital and Institute of Cancer Research, London.Address reprint requests to Dr. Smith at the Breast Unit, Royal Marsden Hospital, Fulham Rd., London SW3 6JJ, United Kingdom, or at Concise summaries and expert physician commentary that busy clinicians need to enhance patient care.The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams.NEW! Aromatase inhibitors can cause a multitude of musculoskeletal symptoms. Diverse cognitive functions in many vertebrate species are influenced by local conversion of androgens to 17β-estradiol (E2) by aromatase. Cos S, Martínez-campa C, Mediavilla MD, Sánchez-barceló EJ. The preponderance of clinical evidence suggests that tamoxifen increases stroke risk and has no effect or modestly reduces CHD risk. The Austrian study included 3,469 postmenopausal women who had been diagnosed with stage I to stage III (early-stage) hormone-receptor-positive breast cancer and had taken 5 years of hormonal therapy between 2004 and 2010.