Life as a ‘normal’ human requires a healthy brain. You may use as… Such patients are rife for a clinical trial comparing dual antiplatelet therapy alone versus dual antiplatelet therapy plus warfarin to determine whether triple therapy is more effective than dual therapy for preventing coronary and cerebral ischemic events and at what risk for bleeding side effects. Another vexing clinical situation with little or no information on which to base clinical decision making is the patient with AF who has recently undergone coronary artery stenting, requiring dual antiplatelet therapy to prevent stent thrombosis. Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin) should avoid aspirin because aspirin also thins the blood, and excessive blood thinning may lead to serious bleeding. This drug combination is also used in patients with mechanical heart valves or occasionally in stroke/TIA patients who are deemed to be at high-risk for … So, taking aspirin on top of coumadin with your INR of say 2.5 isn't like taking more coumadin raising your INR and putting you at risk. By continuing to browse this site you are agreeing to our use of cookies.The combined use of warfarin plus aspirin for secondary stroke prevention occurs primarily in patients with atrial fibrillation (AF) who have concomitant coronary artery disease (CAD). The key is finding the right balance, picking the right patient and then discussing risk-tolerance with the patient. Aspirin and clopidogrel (and others now) inhibit platelets from sticking together. "Is it a bad idea to take warfarin and aspirin together?" That’s because NSAIDs like ibuprofen (Advil, Motrin IB, etc) or naproxen (Aleve) can cause irritation and lesions within the GI tract.An anticoagulant like warfarin can lead to a bleeding ulcer. In the typical clinical scenario where such a combination is considered, ie, a patient with stable CAD or recent MI without a coronary stent and AF, there is no evidence of additional benefit of the combination versus warfarin alone. Aspirin and ibuprofen are both used to treat minor pains. The ultimate goal in medicine: protect the patient from stroke. Published in JAMA Internal Medicine, the study discovered that many people who take a blood thinner like warfarin (Coumadin) to reduce … People who have to take a blood thinner like warfarin (Coumadin) are caught in a terrible double bind.If they have pain, they have surprisingly few options. Dual antiplatelet therapy of aspirin and a thienopyridine is the standard of care following coronary stenting. Stuff you take for granted can go away: swallowing, speaking, understanding language, sight, movement of a limb, not drooling, and the list goes on.Aside from living a healthy lifestyle from the get-go, one of the best ways to prevent these catastrophes is to use drugs that inhibit clotting. Post was not sent - check your email addresses! It is estimated that approximately 20% of patients on warfarin also receive aspirin and aside from patients with mechanical heart valves the use of this combination is tenuous.The most common clinical scenario for using warfarin plus aspirin is for primary or secondary stroke prevention in AF patients who also have CAD. If you follow your doctor's dosing instructions and tell all your health care providers that you take warfarin, you'll be at a much lower risk of dangerous interactions and side effects. The basis for this assumption is unclear, and the combined use of warfarin plus aspirin substantially increases the risk of major bleeding side effects, including intracerebral hemorrhage (ICH).If warfarin usage alone is associated with an increased bleeding risk, what are current estimates of the bleeding risk for warfarin plus aspirin? In short, most people shouldnt. The combined use of warfarin plus aspirin for secondary stroke prevention occurs primarily in patients with atrial fibrillation (AF) who have concomitant coronary artery disease (CAD).