COVID-19 is an emerging, rapidly evolving situation. DiNicolantonio JJ, Bhutani J, Lavie CJ, O'Keefe JH.Future Cardiol. Cochrane Database Syst Rev. Unable to load your collection due to an error COVID-19 is an emerging, rapidly evolving situation. The authors summarize the literature comparing these two agents. Practical issues The onset of diuretic effect is usu - ally observed within one hour and may last for about 12 hours. 2014 May 29;(5):CD003824. HighWire Thiazide diuretics enhance the effectiveness of most other antihypertensive agents, especially vasodilators such as hydralazine and minoxidil, which by themselves promote volume expansion. Hydrochlorothiazide 25-200 mg daily, chlorothiazide 500 mg twice daily, and indapamide … However, evidence from this and other clinical trials have also found an increased incidence of new onset diabetes among those patients receiving thiazide diuretics. Clipboard, Search History, and several other advanced features are temporarily unavailable. The antihypertensive effect is more gradual in onset and more long-lasting. When a diuretic … The mechanisms responsible for the increased incidence of diabetes with thiazide diuretics … Please enable it to take advantage of the complete set of features! Unable to load your delegates due to an error This site needs JavaScript to work properly. Agents studied include hydrochlorothiazide, chlorothiazide, indapamide, and metolazone, with results varying by drug and patient population. Hydrochlorothiazide is the most commonly used thiazide diuretic in the United States, but interest in chlorthalidone is increasing. As of early 2014, the first-choice treatment for hypertension in nondiabetic adults without cardiovascular or renal disease should be chlortalidone. This site needs JavaScript to work properly. Atypon Peterzan et al 1 have provided an important new meta-analysis of the dose-response relationships for 2 different thiazide diuretics and 1 thiazide-like diuretic. National guidelines and a recent clinical trial have supported the use of thiazide diuretics as the preferred initial pharmacological treatment for hypertension. Free or fixed combination therapy with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and calcium-channel blockers or thiazide-like diuretics … If chlortalidone is not available, it appears reasonable to choose another thiazide diuretic, hydrochlorothiazide, possibly combined with amiloride or triamterene. Thiazide diuretics can be given as monotherapy for primary hypertension or as an adjunct agent. Epub 2011 Jul 27.Curr Hypertens Rep. 2014 Sep;16(9):467. doi: 10.1007/s11906-014-0467-3. Thiazide diuretics can also mobilize mild edema and are sometimes used for this purpose, but loop diuretics are generally … First-line treatment of hypertension with thiazide diuretics has been shown to significantly reduce serious cardiovascular morbidity (stroke and myocardial infarction [MI]) and mortality in randomised controlled trials, with benefits at least as great as first-line treatment with other classes of antihypertensive drug [3,4,5,6]. eCollection 2016. Thiazide diuretics can provoke hyperglycaemia and diabetes, although this does not reduce their efficacy in the prevention of cardiovascular events. These drugs can be considered as first-line agents for the management of isolated systolic hypertension. Thiazide diuretics and dihydropyridine calcium-channel blockers are the primary compounds used in randomized clinical trials. 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