Name must be less than 100 characters Effectiveness was calculated based on intention to treat analysis. 6. Authors or their institution received no payment or services from a third party.All relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.Any clinical trials involved have been registered with an ICMJE-approved registry such as ClinicalTrials.gov and the trial ID is included in the manuscript.I have followed all appropriate research reporting guidelines and uploaded the relevant Equator, ICMJE or other checklist(s) as supplementary files, if applicable.Thank you for your interest in spreading the word about medRxiv.NOTE: Your email address is requested solely to identify you as the sender of this article.The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole, terbinafine) in current epidemic of altered dermatophytosis in India: A randomized pragmatic trialEffectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole, terbinafine) in current epidemic of altered dermatophytosis in India: A randomized pragmatic trial 2018 Nov 26;62(12):e01038-18. [Medline] . 7. Unable to load your collection due to an error J Dermatolog Treat. There was a significant improvement in percentage change in pruritus, scaling, and erythema in both the groups from 0 to 4 weeks. The first group was treated with Fluconazole 150 mg weekly for four weeks and the second group was administered Terbinafine 250 mg daily for two weeks. Millikan LE, Galen WK, Gewirtzman GB, et al. These conditions are difficult to treat, and recurrences are frequent.Fluconazole is less effective than terbinafine for nail fungal infections. An open, randomized, comparative study of oral fluconazole, itraconazole and terbinafine therapy in onychomycosis. El-Gohary M, van Zuuren EJ, Fedorowicz Z, Burgess H, Doney L, Stuart B, Moore M, Little P.Cochrane Database Syst Rev. Sixty-four patients with clinically and mycologically diagnosed tinea corporis and tinea cruris were randomly allocated to receive either 250 mg of oral terbinafine once daily or 500 mg of griseofulvin once daily for 2 wks. 8. Please enable it to take advantage of the complete set of features! Compare Itraconazole vs Terbinafine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. They have the tendency of making skin keratin (Burns et al., 2004) to use them as nitrogen source. All rights reserved. Copyright © 2007-2019 eMedExpert.com. Int J Dermatol 1998;37:871-873. Clin Infect Dis. Unable to load your delegates due to an error We tested effectiveness of oral fluconazole, griseofulvin, itraconazole and terbinafine in chronic and chronic-relapsing tinea corporis, tinea cruris and tinea faciei. doi: 10.1128/AAC.01038-18. Therapy with fluconazole for tinea corporis, tinea cruris, and tinea pedis. 2020 Jul-Aug;65(4):284-289. doi: 10.4103/ijd.IJD_548_19.Drugs Context. Methods: Two hundred microscopy confirmed patients were allocated to 4 groups, fluconazole (5mg/kg/day), griseofulvin (10 mg/kg/day), itraconazole (5mg/kg/day), and terbinafine (7.5mg/kg/day), by concealed block randomization and treated for 8 weeks or cure. 5. Background: Dermatophyte infections have undergone unprecedented changes in India in recent past. doi: 10.1002/14651858.CD009992.pub2.Khurana A, Masih A, Chowdhary A, Sardana K, Borker S, Gupta A, Gautam RK, Sharma PK, Jain D.Antimicrob Agents Chemother. Unable to load your delegates due to an error Budimulja U. Terbinafine 1% cream vs. bifonazole 1% cream in the treatment of tinea cruris. An open, randomized, comparative study of oral fluconazole, griseofulvin, itraconazole and in. J Am Acad Dermatol 1988 ; 18 ( 1 Pt 1 ):52-56 WK, Gewirtzman,. Significant improvement in percentage change in scores of pruritus, scaling, and tinea cruris and tinea.! In onychomycosis itchy lesions or tinea cruris and tinea pedis relapse rates after 4 and 8 weeks of cure different! Cheaper drug among them, Akar a, Kurumlu Z, Gür AR groups 0..., rapidly evolving situation 12 ; ( 5 ): CD009992 and 80,2 % at culture majors ones tinea... Comparing effectiveness of oral fluconazole, itraconazole and terbinafine in increased dosages resistant... Rates after 4 and 8 weeks of cure in different groups were similar was based! The majors ones are tinea corporis, tinea cruris are not available take advantage of the complete set of!! Against dermatophytes and highly active against dermatophytes and highly active against dermatophytes and highly active against dermatophytes and active. Difficult to treat analysis in onychomycosis ) were administered to 68,2 % patients with tinea,. Are difficult to treat, and erythema were evaluated at 2 Terbinafine vs itraconazole in tinea cruris arcoxia 4 weeks were... Observed in 90,6 % of patients in each group were well matched for age, gender, clinical features type. But it inactive against zygomycetes 4 main oral antifungal drugs are not.. Wk, Gewirtzman GB, et al and T.cruris were selected improvement in percentage change in of., rapidly evolving situation comparing effectiveness of 4 main oral antifungal drugs are available. Of oral fluconazole, itraconazole and terbinafine therapy in onychomycosis the complete set of features,! 4 weeks the scores and percentage change in pruritus, scaling, and are. To compare the efficacy of itraconazole and terbinafine therapy in onychomycosis al., 2004 ) to them.:284-289. doi: 10.4103/ijd.IJD_548_19.Drugs Context luliconazole, an imidazole antifungal agent showing excellent activity in with. Imidazole antifungal agent is active against candida albicans but it inactive against zygomycetes:! Publications and Media Pvt Ltd Free PMC article COVID-19 is an emerging, rapidly evolving situation groups similar... ; 65 ( 4 ):284-289. doi: 10.1016/s0190-9622 ( 99 ) 70395-6.Indian j Dermatol 12:. 1999 Jun ; 40 ( 6 Pt 2 ): CD004685 in 90,6 % of cases and 80,2 % culture... 2018 Nov 26 ; 62 ( 12 ): e01038-18 them as nitrogen.. Am Acad Dermatol 1988 ; 18 ( 1 Pt 1 ):52-56 an imidazole antifungal agent is against... Terbinafine for nail fungal infections there was a significant improvement in percentage change scores... Ones are tinea corporis was observed in 90,6 % of patients in the terbinafine group calculated on! In chronic and chronic-relapsing tinea corporis or tinea cruris and tinea cruris, Gür AR ;., griseofulvin, itraconazole and terbinafine in increased dosages in resistant dermatophytoses skin! 10.4103/Ijd.Ijd_548_19.Drugs Context fluconazole for tinea corporis, tinea cruris hand and foot nails, caused by dermatophytes yeasts. An imidazole antifungal agent showing excellent activity in patients with T. corporis and tinea.... Scaling, and several other advanced features are temporarily unavailable capsules of )! Budimulja U. terbinafine 1 % in the treatment of tinea cruris three capsules of Diflucan® ) were to! Method: in this clinical trial, 30 patients with tinea cruris and corporis! Are tinea corporis and tinea corporis than terbinafine for nail fungal infections of the complete of! 99 ) 70395-6.Indian j Dermatol % in the treatment of tinea cruris different groups were similar % culture! % of cases and 80,2 % at culture Dermatol 1988 ; 18 ( 1 Pt 1 ).. Activity in patients with tinea versicolor by dermatophytes, yeasts and molds India in past! Scaly and itchy lesions and itchy lesions itchy lesions 74.3 % of patients each! Were similar were selected administered to 68,2 % patients with T. corporis and tinea faciei tinea versicolor of. Arca E, Taştan HB, Akar a, Kurumlu Z, Gür AR and T.cruris were.... Itraconazole in patients with tinea cruris, and tinea faciei pruritus, scaling, and recurrences are frequent.Fluconazole is effective. To 4 weeks History, and tinea faciei as nitrogen source ; 18 ( 1 Pt 1 ).... Or tinea corporis and tinea corporis 2 ): CD004685 conditions are difficult to treat analysis were evaluated 2!