It should be used with caution in these patient populations.Serious adverse reactions include paradoxical bronchospasm, cardiovascular effects, immediate hypersensitivity reactions, and hypokalaemia.Adverse reactions reported (≥2% of patients) in a 4-week, controlled clinical trial in adults and adolescents aged12 years and older were allergic reactions, flu syndrome, chills, chest pain, accidental injury, pain, back pain, tachycardia, migraine, dyspepsia, leg cramps, dizziness, hypertonia, nervousness, tremor, anxiety, increased cough, viral infection, rhinitis, sinusitis and turbinate oedema.In the clinical trials, a slightly greater number of serious adverse events, discontinuations due to adverse events, and clinically significant ECG changes were reported in patients who received levosalbutamol sulphate inhalation solution 1.25 mg compared with the other active treatment groups.Most frequently reported adverse reactions (≥2% in any treatment group) and those reported more frequently than in placebo during the double-blind period (6 to 11 years old) were abdominal pain, accidental injury, asthenia, fever, headache, pain, viral infection, diarrhoea, lymphadenopathy, myalgia, asthma, pharyngitis, eczema, rash, urticaria and otitis media.The following adverse reactions, considered potentially related to levosalbutamol sulphate inhalation solution, occurred in less than 2% of the 292 subjects who received levosalbutamol sulphate inhalation solution and more frequently than in patients who received placebo in any clinical trial – ECG abnormal, ECG change, hypertension, hypotension, syncope, diarrhoea, dry mouth, dry throat, dyspepsia, gastroenteritis, nausea, lymphadenopathy, leg cramps, myalgia, anxiety, hyperaesthesia of the hand, insomnia, paraesthesia, tremor, eye itch.In addition to the adverse reactions reported in clinical trials, the following adverse reactions have been observed in post-approval use of levosalbutamol sulphate inhalation solution. Good evening doctor My son (20 months) was hospitalised from 9-17 April for bronchitis and severe tonsilitis. Clinically significant changes in systolic and diastolic blood pressure have been seen in individual patients and could be expected to occur in some patients after the use of any beta-adrenergic bronchodilator. When racemic albuterol sulphate was administered either intravenously or via inhalation after oral charcoal administration, there was a 3- to 4-fold difference in the area under the concentration-time curves between the (R)- and (S)-albuterol enantiomers, with (S)-albuterol concentrations being consistently higher. Immediate hypersensitivity reactions following the use of ipratropium bromide have been demonstrated by rare cases of urticaria, angio-oedema, rash, bronchospasm, oropharyngeal oedema and anaphylaxis. Answered by : Dr. Ashakiran S ( General & Family Physician) Bronchitis attack, respules, duolin respules MD. health I am suffering from bronchitis since my childhood & now I … Regular monitoring of kidney function tests is necessary while receiving this medicine. Duolin Respules is used to relieve symptoms of COPD (Chronic Obstructive Pulmonary Disease) like breathing difficulties, coughing and whistling sound while breathing and tightness in the chest. It is a medication which contains Ipratropium Bromide and Salbutamol as active ingredients. People with liver related issues must avoid this medicine in order to not experience any serious implications. In a randomised, double-blind, placebo-controlled, cross-over study, 12 adults with mild-to-moderate asthma were challenged with inhaled methacholine chloride 20 and 180 minutes following administration of a single dose of 2.5 mg of racemic albuterol sulphate, 1.25 mg of levosalbutamol sulphate inhalation solution, 1.25 mg of (S)-albuterol, or placebo using a Pari LC Jet™ nebulizer.