Fluticasone Propionate/Salmeterol DISKUS should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of salmeterol, a component of Fluticasone Propionate/Salmeterol DISKUS, on the vascular system may be potentiated by these agents.Beta-blockers not only block the pulmonary effect of beta-agonists, such as salmeterol, a component of Fluticasone Propionate/Salmeterol DISKUS, but may also produce severe bronchospasm in patients with asthma or COPD. imaginable degree, area of Patients should taper slowly from systemic corticosteroids if transferring to Fluticasone Propionate/Salmeterol DISKUS.Advise patients that immediate hypersensitivity reactions (e.g., urticaria, angioedema, rash, bronchospasm, hypotension), including anaphylaxis, may occur after administration of Fluticasone Propionate/Salmeterol DISKUS. No terminal half-life estimates were calculated for salmeterol following administration of fluticasone propionate/salmeterol DISKUS.A population pharmacokinetic analysis was performed for fluticasone propionate and salmeterol utilizing data from 9 controlled clinical trials that included 350 subjects with asthma aged 4 to 77 years who received treatment with fluticasone propionate/salmeterol DISKUS, the combination of HFA-propelled fluticasone propionate and salmeterol inhalation aerosol (ADVAIR HFA), fluticasone propionate inhalation powder (FLOVENT DISKUS), HFA-propelled fluticasone propionate inhalation aerosol (FLOVENT HFA), or CFC-propelled fluticasone propionate inhalation aerosol. Find out what health conditions may be a health risk when taken with Fluticasone … Although the distribution of adverse events was similar in the 2 age groups, subjects older than 65 years experienced more severe events. See full prescribing information for Fluticasone Propionate/Salmeterol DISKUS. Fluticasone and salmeterol is a combination of two medicines that are used to help control the symptoms of asthma and improve breathing. Based on the available data, the concomitant administration of methylxanthines with fluticasone propionate/salmeterol DISKUS did not alter the observed adverse event profile. COPD exacerbations were considered of moderate severity if treatment with systemic corticosteroids and/or antibiotics was required and were considered severe if hospitalization was required.Exacerbations were also evaluated as a secondary outcome in the 1- and 3-year trials with fluticasone propionate/salmeterol DISKUS 500/50 mcg. Open your Fluticasone Propionate/Salmeterol DISKUS.Breathe out slowly as long as you can. In addition, clinical trials showed similar results between fluticasone propionate/salmeterol DISKUS and the concurrent use of fluticasone propionate plus salmeterol at corresponding doses from separate inhalers.Predefined withdrawal criteria for lack of efficacy, an indicator of worsening asthma, were utilized for this placebo-controlled trial. Advair HFA), budesonide-formoterol (Symbicort), formoterol-mometasone (Dulera) and fluticasone furoate-vilanterol (Breo Ellipta). Cleft palate, fetal death, increased implantation loss, and delayed ossification were observed in mouse fetuses when combining fluticasone propionate at a dose approximately 0.7 times the MRHDID (on a mcg/mIn an embryofetal development study with pregnant rats dosed by the inhalation route throughout the period of organogenesis, fluticasone propionate produced decreased fetal body weights and skeletal variations, in the presence of maternal toxicity, at a dose approximately 0.25 times the MRHDID (on a mcg/mIn an embryofetal development study in pregnant rabbits that were dosed by the subcutaneous route throughout organogenesis, fluticasone propionate produced reductions of fetal body weights, in the presence of maternal toxicity, at doses approximately 0.012 times the MRHDID and higher (on a mcg/mFluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits.In a pre- and post-natal development study in pregnant rats dosed by the subcutaneous route from late gestation through delivery and lactation (Gestation Day 17 to Postpartum Day 22), fluticasone propionate was not associated with decreases in pup body weight, and had no effects on developmental landmarks, learning, memory, reflexes, or fertility at doses up to 0.5 times the MRHDID (on a mcg/mIn 2 embryofetal development studies, pregnant rats received salmeterol by oral administration at doses ranging from 100 to 10,000 mcg/kg/day during the period of organogenesis. 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