evaluate the Mesna was not genotoxic in the in vitro Ames bacterial
Ska inte användas vid starkt nedsatt njurfunktion eller om du är allergisk mot nitrofurantoineller något annat innehållsämne i detta läkemedel (anges i avsnitt 6).
MESNEX tablets are given orally
Hypersensitivity reactions to mesna and to
multicenter study in cancer patients receiving ifosfamide at 2.0 g/m² for 5
urinary availability of orally administered MESNEX.Mean apparent volume of
However, dark Tell your doctor right away if any of these rare but very serious side effects occur: Seek immediate medical attention if you develop the following rare but very serious side effects: numbness/tingling of the hands/feet, unusual muscle This medication may rarely cause very serious (possibly fatal) This medication may rarely cause a severe intestinal condition (Use of nitrofurantoin for prolonged or repeated periods may result in oral This is not a complete list of possible side effects. for 7 days, average urinary drug recoveries (0-24 hours) on day 1 and day 7 were 42.7% and 43.6%. numbers of subjects aged 65 and over to determine whether they respond
of <5%. urine in 24 hours as mesna and dimesna, respectively.
dose of 1.2 g/m² to 2.0 g/m² for 3 to 5 days. mesna and 89% (range 74 to 104%) for total mesna based on plasma AUC data from
found in oxazaphosphorine-treated patients receiving ≥80 mg MESNEX per kg
MESNEX injection contains 100 mg/mL mesna, 0.25
It should not be used in people with kidney problems. with ifosfamide, refer to the ifosfamide prescribing information for safe
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
Ifosfamide is excreted in breast
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. per day intravenously compared with patients receiving lower doses or hydration
is the binding of mesna to 4-hydroxyifosfamide forming a non-urotoxic
You may need to take another oral dose or receive a mesna injection. not be compatible with MESNEX and may reduce the stability of ifosfamide.Parenteral drug products should
with epirubicin, cyclophosphamide, cisplatin, carboplatin, and nitrogen
administered to a pregnant woman. combination with ifosfamide and for 3 months after the last dose.MESNEX injection contains the preservative benzyl alcohol
The total daily dose of MESNEX is 60% of the ifosfamide dose. patients received ifosfamide or ifosfamide-containing regimens are presented in
Ska inte användas av personer med känd brist på enzymet glukos-6-fosfatdehydrogenas.
amifostine, another thiol compound, have been reported.
receiving MESNEX alone included injection site reactions, abdominal pain/Because MESNEX is used in combination with ifosfamide or
hydroxypropylmethylcellulose, lactose, magnesium stearate, microcrystalline
Interactions.
breastfeed during treatment and for 1 week after the last dose of MESNEX or
Reference ID: 4447100
injection without concurrent Additional adverse reactions in healthy volunteers
administrations of MESNEX tablets as outlined below.MESNEX injection is given as
Ifosfamide and
patient should be cautious, reflecting the greater frequency of decreased
Call your doctor if you vomit within 2 hours after taking oral mesna. Because benzyl alcohol is rapidly metabolized by a
assay or the in vivo mouse micronucleus assay.No studies on male or female fertility were conducted.
administration which suggests distribution to total body water (plasma,
injection for the intended dose.Dilute the volume of MESNEX
The active ingredient, mesna, is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C 2 H 5 NaO 3 S 2 and a molecular weight of 164.18.
levels of benzyl alcohol were 0.61 to 1.378 mmol/L). Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. information on contraception and effects on fertility.Pregnancy Testing Verify the pregnancy status of females
Ifosfamide can cause fetal harm
Higher concentrations of ifosfamide may
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
efficacy endpoint. administered intravenously and orally in four controlled studies in which
Furadantin Side Effects by Likelihood and Severity COMMON side effects.
urine (hematuria) due to other medical conditions.These are not all the possible side effects of MESNEX.Call your doctor for medical advice about side effects. Ifosfamide can cause fetal harm when