Prodrug formation may increase the duration of action. Bulk density of a compound varies substantially with the method of crystallization, milling or formulation once a density problem is identified it is often easily corrected by milling slugging or formulation.It can affect powder flow properties.It affects the size of high dose capsule product or the homogeneity of a low dose formulation in which there are large differences in drug and excipients densities.The flow properties of powders are critical for an efficient tablet operation.During the pre-formulation evaluation of the drug substance, therefore, its flow ability characteristic should be studied, especially when the anticipated dose of the drug is large.Powders may be free flowing or cohesive (non free flowing).Flow properties are affected by changes in particle size, density, shape, electrostatic charges, and adsorbed moisture. If pH is above 9, tissue necrosis may result while below 3, pain and phlebitis in tissue can occur. Methods to improve drug solubility are chemical modification of the drug into salt or ester forms, through selection of a different solubilizing agent, use of co‐solvents or other techniques such as micronization or solid dispersion and adjustment of the pH of the solvent in which the drug is to bedissolved.For acidic compounds pH=pKa + log (ionized drug/ unionized drug)For basic compounds pH= Pkw ‐ pKb + log (unionized drug/ionized drug)The ideal pH of parenteral products is pH 7.4. Significances of identification of crystal shape and internal structure can influence by Solubility and stability-For example: Chloramphenicol palmitate exists in 3 crystalline polymorphic forms (A, B and C) and an amorphous form (D). Applicable for the pharmaceutical industry, Pharmaceutical Pellets can be defined as the little, free-flowing, spherical particulate matters produced by the accumulation of grains of drug substances or fine powders and excipients, by utilizing the most appropriate processing equipments. E.g. Applicable for the pharmaceutical industry, Pharmaceutical Pellets can be defined as the little, free-flowing, spherical particulate matters produced by the accumulation of grains of drug substances or fine powders and excipients, by utilizing the most appropriate processing equipments. Solution and suspension toxicological preparation should be checked for ease of manufacture and stored in flame-sealed ampoules at various temperatures. ... good solubility in water, Eur. I. MDL number MFCD00083597. Available for Android and iOS devices. Prodrug formation may increase the absorption rate due to its lipophilicity (passive) or its water solubility (active). For example, orally administered drug should be examined for solubility in simulated gastric media. Insuring a good health of animals, these optimal quality intermediates are commendable for their instant health advantages. The chemicals are well-capable to control crop-harming organisms (such as nematodes, insects, rodents, mites, fungi) or viruses. It is essential to establish as early as possible how the particle size of the drug substance may affect formulation and product efficacy. In suppositories changes in polymorphic forms could cause product with different and unacceptable melting characteristic (failure to melt after administration or premature melting during storage). EC Number 208-477-9. https://www.youtube.com/c/SocietyofPharmaceuticalSciencesandResearch This property is used in proper selection of the formulation ingredients.It is possible to observe on the bases of size, shape, appearance and determined instrumentally or visually.One important goal of the pre‐formulation effort is to devise a method for making solutions of the drug. Figure 2b,c shows the measured solubility of two polymorphic forms of chloramphenicol palmitate in water and sulfathiazole in 1-propanol, respectively, as a function of temperature (symbols). It can be classifies as Internal structures (cubic, tetragonal, hexagonal, rhombic, etc. It focuses on drug‐solvent interactions that could occur during the delivery of a drug candidate. So, it is modified in the form of the salt Ephedrine HCL that is ionized and offer higher water solubility and dissolution rate. 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