All antipsychotics produce extrapyramidal side effects (EPS), such as acute dystonic reactions, which can cause respiratory difficulty by pharyngeal and laryngeal muscle spasm. It is an atypical anipsychotic that is used to treat Psychotic Disorders and Bipolar Disorder. 800-638-3030 (within USA), 301-223-2300 (international)Registered users can save articles, searches, and manage email alerts.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. By continuing to use this website you are giving consent to cookies being used. On admission, she was hypotensive, with an arterial blood pressure (BP) of 80/50 mm Hg, and she had a Glasgow Coma Scale (GCS) score of 8 of 15.
The half-lives of risperidone and its metabolite are 3 and 7 h, respectively.
Risperidone overdose is rare but life-threatening. Overdose of risperidone. Message:
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Overdose and treatment Signs and symptoms of overdose reflect exaggeration of risperidone effects, such as drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Her reported GCS was 13. Rassam and Srinivasa (In this case, we evaluated whether acute dystonic reaction contributed to the clinical course of our patient, who demonstrated lethargy, tongue protrusion, and pharyngeal-laryngeal muscle spasm, all of which were related to respiratory dysfunction.Experience with risperidone overdose is limited and the clinical presentation difficult to predict after an overdose. There was no history of any other concurrent drug overdose. Your Name: (optional) Am J Psychiatry 1975;132:532–7.4. A chest radiograph showed no abnormality. 800-638-3030 Message: For information on cookies and how you can disable them visit our You may be trying to access this site from a secured browser on the server. Huttunen M. The evolution of the serotonin-dopamine antagonist concept. Psychopharmacology (Berl) 1986;88:403–5.3.
She was tracheally extubated on Day 6 and discharged from the ICU on Day 8.Toxicity of antipsychotic drugs results from unintentional or intentional overdose or from adverse reactions after therapeutic administration. Himstreet JE, Daya M. Hypotension and orthostasis following a risperidone overdose.
After 6 h, she managed to breathe spontaneously with a continuous positive airway pressure mode. We report on a 17-year-old boy who developed a marked increase in serum creatine kinase (CK) (9743 U/l) during treatment with risperidone for catatonic psychosis. This article has been saved into your User Account, in the Favorites area, under the new folder Hyponatremia, hypokalemia, prolonged QT interval, widened QRS complex, and seizures also have been reported. Treating a Risperidone overdose usually depends on the time when the medication was taken. Risperidone is not a treatment for ADHD. Known causes of elevated CK such as delirium, malignant neuroleptic syndrome, infection, cocaine overdose, trauma, and intramuscular inje … Your Email: Rupniak NMJ, Jenner P, Marsden CD. Vecchio FL, Hamilton RJ, Hoffman RJ. We report the first case of a risperidone overdose in an apparent suicide attempt. Sweet C. Drug-induced dystonia. J Clin Psychopharmacol 1995;15:4–8.2. to maintaining your privacy and will not share your personal information without Please try after some time.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. The blood gas analysis at this time, under OThe patient started to make respiratory efforts on Day 5. Address e-mail to Risperidone is an atypical antipsychotic drug used for the treatment of schizophrenia. Intuniv can be used to treat ADHD, though it is not usually chosen as a 'front line' (i.e., first choice) medication to treat ADHD. Patients were seen in local Philadelphia-area emergency departments. may email you for journal alerts and information, but is committed Your Name: (optional) Your Email: doi: 10.1213/01.ANE.0000180195.57760.E91.