contain L-Asparaginase. Side effects following the use of vincristine sulfate injection (vincristine sulfate) are dose related. These drugs are called vesicants. There are also many options to help lessen the side effects for your pet while he or she is under going treatment.This is one of the more common side effects and may occur after a dose of any chemotherapeutic drug. its active ingredients. In pediatric patients under 13 years of age, death has occurred following doses of vincristine sulfate that were 10 times those recommended for therapy. from bladder stones may suffer from high uric acid levels after they’re Cheltenham: BSAVA. Besides this, pets that have previously suffered Although the drug works effectively to reduce cell division, there Do not use products like Imodium or Lomotil as these tend to stop intestinal motility.Increased hunger, thirst and/or urination are not side effects of chemotherapeutic drugs, but are a side effect of some of the drugs used in conjunction with the chemotherapy treatment.Some chemotherapeutic drugs such as Elspar (L-asparaginase), Doxorubicin (Adriamycin), and Paclataxol can trigger an anaphylactic (allergic) reaction. intravenously once every 7 days. Diarrhea sometimes takes several days to a week to resolve.One at home remedy is adding white rice to your pet’s food to bulk up the stool. vet’s instructions when administering any drugs to your pet. Philadelphia, PA, Mosby. If your pet experiences a loss of appetite, feed him or her frequent, small meals.It’s preferable to keep your pet on normal food, but you may need to introduce some bland food to increase your pet’s interest in eating. they effectively work on cancer cells that cannot be removed through given Vincristine. Adriamycin (Doxorubicin) and Doxil can cause very severe damage, which may require surgery to repair.Great precaution is taken when giving these drugs, including placing an indwelling intravenous catheter and diluting the drug. Vincristine may cause hair loss, vomiting, nausea or diarrhea. To prevent Although smaller doses of chemotherapy are given to pets, that doesn’t mean that your pet will not have side effects from the treatment. administered exactly according to the administration protocols that are Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook.6th edn. Vincristine is a prescription medicine formulated to help moderate the growth of cancerous tumors. normal cells. Charlie is an awesome Golden Retriever I am treating with the UW (University of Wisconsin) protocol for lymphoma. Do not use human products like Kaopectate or Pepto-Bismol as these contain aspirin products. As with most other chemotherapy drugs, there are a few side effects associated with the use of Vincristine. Other sources of information. If the pet develops any of Due to this reason Vincristine should be Grau-Bassas E R et al (2000) Vincristine impairs platelet aggregation in dogs with lymphoma. As you might expect, this treatment protocol combines the chemotherapy drugs used […] There are also many options to help lessen the side effects for your pet while he or she is under going treatment. Toxic effects of vincristine can affect the nervous system, resulting in weakness, collapse or seizure. Severe symptoms may occur in this patient group following dosages of 3 to 4 mg/m². to the doctor for the same purpose. Some vesicants will cause minor irritation (Vincristine, Vinblastine, and Mitoxantrone). associated with the use of tissues present in the pet’s body, the drug has to only be administered To prevent, pets will be given an antihistamine, an anti-emetic (anti-nausea) and sometimes a steroid prior to administration of chemotherapy to minimize the risk.Some drugs must be delivered directly into the vein only because they can damage other types of tissues. pp 234-236. Ramsey I (2017) 9th edn. the side effects after he is administered the drug, you should seek Although smaller doses of chemotherapy are given to pets, that doesn’t mean that your pet will not have side effects from the treatment. These drugs are helpful in curing dogs suffering from cancer because put forth by the Food and Drug Administration (FDA). 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